Thrive Science Institute

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Clinical Research

  1. Cancer Lett. 1997 Mar 19;114(1-2):221-3. Modulation of aflatoxin B1 carcinogenicity, genotoxicity and metabolism in rat liver by dietary carotenoids: evidence for a protective effect of CYP1A inducers. Gradelet S1, Astorg P, Le Bon AM, Bergès R, Suschetet M.
  2. Vopr Pitan. 1987 Jul-Aug;(4):61-3. Effect of vitamin A deficiency on surfactants and enzymes of xenobiotic metabolism in the rat lung. [Article in Russian] Iakovleva OA, Pentiuk AA, Gutsol VI, Bogdanov NG.
  3. Vopr Med Khim. 1986 Mar-Apr;32(2):130-4. Activity of enzymes of xenobiotic metabolism in the liver of rats with vitamin A deficiency and mycotoxicosis T-2. [Article in Russian] Kranauskas AE, Kravchenko LV, Kon' IIa, Tutel'ian VA.
  4. Int J Vitam Nutr Res. 1976;46(1):14-23. Hepatic drug metabolism and lipid peroxidation in thiamine deficient rats. Galdhar NR, Pawar SS.
  5. Vopr Med Khim. 1988 May-Jun;34(3):45-8. Metabolism and toxicity of various xenobiotics in vitamin B1 deficiency and after administration of thiamine and thiamine diphosphate. [Article in Russian] Lychko AP, Pentiuk AA, Lutsiuk NB.
  6. Arch Biochem Biophys. 2008 Jul 15;475(2):93-9. doi: 10.1016/j.abb.2008.04.014. Epub 2008 Apr 20. Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase. Kranendonk M1, Marohnic CC, Panda SP, Duarte MP, Oliveira JS, Masters BS, Rueff J.
  7. Biochim Biophys Acta. 2014 Jul;1840(7):2289-98. doi: 10.1016/j.bbagen.2014.03.019. Epub 2014 Apr 3. Ascorbic acid deficiency affects genes for oxidation-reduction and lipid metabolism in livers from SMP30/GNL knockout mice. Takahashi K1, Kishimoto Y1, Konishi T2, Fujita Y3, Ito M3, Shimokado K4, Maruyama N5, Ishigami A6.
  8. Arch Biochem Biophys. 2004 Mar 1;423(1):6-11. Vitamin E, nuclear receptors and xenobiotic metabolism. Traber MG1.
  9. Drug Metab Dispos. 2015 Jan;43(1):126-39. doi: 10.1124/dmd.114.060350. Epub 2014 Oct 22. Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation. Manevski N1, Swart P1, Balavenkatraman KK1, Bertschi B1, Camenisch G1, Kretz O1, Schiller H1, Walles M1, Ling B1, Wettstein R1, Schaefer DJ1, Itin P1, Ashton-Chess J1, Pognan F1, Wolf A1, Litherland K2.
  10. Toxicon. 2007 Sep 1;50(3):339-48. Epub 2007 Apr 22. The effect of feeding piglets with the diet containing green tea extracts or coumarin on in vitro metabolism of aflatoxin B1 by their tissues. Tulayakul P1, Dong KS, Li JY, Manabe N, Kumagai S.
  11. Environ Toxicol Pharmacol. 2009 Jan;27(1):120-6. doi: 10.1016/j.etap.2008.09.004. Epub 2008 Sep 23. Taurine enhances the metabolism and detoxification of ethanol and prevents hepatic fibrosis in rats treated with iron and alcohol. Devi SL1, Viswanathan P, Anuradha CV.
  12. Life Sci. 1995;56(22):1845-55. Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential.Surh YJ1, Lee SS.
  13. J Am Diet Assoc. 2003 Aug;103(8):1029-38. Nutritional cofactor treatment in mitochondrial disorders. Marriage B1, Clandinin MT, Glerum DM.
  14. Free Radic Biol Med. 1992;12(5):397-407. Role of physiological antioxidants in chromium(VI)-induced cellular injury. Sugiyama M1.
  15. J Int Med Res. 2011;39(6):2330-4. Long-term, high intake of vitamin C decreases size and increases quantity of liver mitochondria in Guinea-pigs. Feuring M1, Schultz A, Hersemeyer K.
  16. J Biol Chem. 2003 Sep 26;278(39):37948-56. Epub 2003 Jul 3. NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons. Lee JM1, Shih AY, Murphy TH, Johnson JA.
  17. Nutr Res. 2014 Nov;34(11):907-29. doi: 10.1016/j.nutres.2014.07.010. Epub 2014 Jul 18. Carotenoids, inflammation, and oxidative stress--implications of cellular signaling pathways and relation to chronic disease prevention. Kaulmann A1, Bohn T2.
  18. FASEB J. 2013 Feb;27(2):612-21. doi: 10.1096/fj.12-209361. Epub 2012 Nov 12. Tissue-specific oxidative stress and loss of mitochondria in CoQ-deficient Pdss2 mutant mice. Quinzii CM1, Garone C, Emmanuele V, Tadesse S, Krishna S, Dorado B, Hirano M.
  19. Xenobiotica. 2016 Jan;46(1):25-33. doi: 10.3109/00498254.2015.1049576. Epub 2015 Jul 30. Interplay of metabolizing enzymes and transporter of xenobiotics. Lim HY1, Ho QS1, Wong KP1.
  20. Arch Pharm Res. 2005 Mar;28(3):249-68. Induction of phase I, II and III drug metabolism/transport by xenobiotics. Xu C1, Li CY, Kong AN.
  21. J Hazard Mater. 2009 Aug 30;168(1):319-25. doi: 10.1016/j.jhazmat.2009.02.026. Epub 2009 Feb 20. Removal of lead and zinc ions from water by low cost adsorbents. Mishra PC1, Patel RK.
  22. Arch Pharm Res. 2013 Sep;36(9):1140-8. doi: 10.1007/s12272-013-0110-x. Epub 2013 Apr 17. Hepatoprotective effect of methylsulfonylmethane against carbon tetrachloride-induced acute liver injury in rats. Kamel R1, El Morsy EM.
  23. World J Gastroenterol. 2014 Oct 28;20(40):14787-804. doi: 10.3748/wjg.v20.i40.14787. Review of natural products with hepatoprotective effects. Madrigal-Santillán E1, Madrigal-Bujaidar E1, Álvarez-González I1, Sumaya-Martínez MT1, Gutiérrez-Salinas J1, Bautista M1, Morales-González Á1, García-Luna y González-Rubio M1, Aguilar-Faisal JL1, Morales-González JA1.
  24. Toxicol In Vitro. 1997 Oct;11(5):669-72. Antioxidant and hepatoprotective effects of artichoke extracts and constituents in cultured rat hepatocytes. Gebhardt R1, Fausel M.
  25. J Nat Prod. 1987 Jul-Aug;50(4):612-7. Hepatoprotective activity of polyphenolic compounds from Cynara scolymus against CCl4 toxicity in isolated rat hepatocytes. Adzet T1, Camarasa J, Laguna JC.
  26. Exp Biol Med (Maywood). 2014 Apr;239(4):465-76. doi: 10.1177/1535370213520112. Epub 2014 Feb 28. D-limonene suppresses doxorubicin-induced oxidative stress and inflammation via repression of COX-2, iNOS, and NFκB in kidneys of Wistar rats. Rehman MU1, Tahir M, Khan AQ, Khan R, Oday-O-Hamiza, Lateef A, Hassan SK, Rashid S, Ali N, Zeeshan M, Sultana S.
  27. Oxid Med Cell Longev. 2015;2015:619560. doi: 10.1155/2015/619560. Epub 2015 Oct 20. Dandelion Extracts Protect Human Skin Fibroblasts from UVB Damage and Cellular Senescence. Yang Y1, Li S2.
  28. Pharmacol Res. 2013 Dec;78:28-40. doi: 10.1016/j.phrs.2013.09.009. Epub 2013 Oct 10. Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes. Kleszczyński K1, Ernst IM, Wagner AE, Kruse N, Zillikens D, Rimbach G, Fischer TW.
  29. Anticancer Res. 1999 May-Jun;19(3A):1887-91. Inhibitory potential of Chlorella vulgaris (E-25) on mouse skin papillomagenesis and xenobiotic detoxication system. Singh A1, Singh SP, Bamezai R.
  30. Cancer Detect Prev. 2005;29(5):470-8. Epub 2005 Sep 26. Amelioration of immune cell number depletion and potentiation of depressed detoxification system of tumor-bearing mice by curcumin. Pal S1, Bhattacharyya S, Choudhuri T, Datta GK, Das T, Sa G.
  31. Biochem Soc Trans. 2003 Dec;31(Pt 6):1390-3. Toxicity of glyoxals--role of oxidative stress, metabolic detoxification and thiamine deficiency. Shangari N1, Bruce WR, Poon R, O'Brien PJ.
  32. FEBS Lett. 2005 Oct 24;579(25):5596-602. Epub 2005 Sep 28. The effects of partial thiamin deficiency and oxidative stress (i.e., glyoxal and methylglyoxal) on the levels of alpha-oxoaldehyde plasma protein adducts in Fischer 344 rats. Shangari N1, Depeint F, Furrer R, Bruce WR, O'Brien PJ.
  33. Biol Trace Elem Res. 2015 Nov;168(1):122-32. doi: 10.1007/s12011-015-0324-5. Epub 2015 Apr 9. Arsenic-Induced Antioxidant Depletion, Oxidative DNA Breakage, and Tissue Damages are Prevented by the Combined Action of Folate and Vitamin B12. Acharyya N1,2,3, Deb B3, Chattopadhyay S3, Maiti S4,5,6.
  34. PLoS One. 2015 Aug 13;10(8):e0131097. doi: 10.1371/journal.pone.0131097. eCollection 2015. Vitamin C Compound Mixtures Prevent Ozone-Induced Oxidative Damage in Human Keratinocytes as Initial Assessment of Pollution Protection. Valacchi G1, Sticozzi C2, Belmonte G2, Cervellati F2, Demaude J3, Chen N4, Krol Y5, Oresajo C4.
  35. Free Radic Biol Med. 2013 Aug;61:151-60. doi: 10.1016/j.freeradbiomed.2013.03.021. Epub 2013 Mar 31. Antioxidant compound supplementation prevents oxidative damage in a Drosophila model of Parkinson's disease. Casani S1, Gómez-Pastor R2, Matallana E3, Paricio N4.
  36. Br J Nutr. 2012 Jun;107(11):1645-54. doi: 10.1017/S0007114511004806. Epub 2011 Sep 16. Effect of ascorbic acid-rich diet on in vivo-induced oxidative stress. Alleva R1, Di Donato F, Strafella E, Staffolani S, Nocchi L, Borghi B, Pignotti E, Santarelli L, Tomasetti M.
  37. Cell Death Dis. 2013 Mar 21;4:e554. doi: 10.1038/cddis.2013.78. Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway. Jin M1, Ande A, Kumar A, Kumar S.
  38. Toxicol Lett. 2006 Sep 30;166(1):27-36. Epub 2006 May 16. Tissue-specific effect of ascorbic acid supplementation on the expression of cytochrome P450 2E1 and oxidative stress in streptozotocin-induced diabetic rats. Ahn T1, Yun CH, Oh DB.
  39. Indian J Biochem Biophys. 2003 Oct;40(5):309-14. Cytochrome P450-mediated oxidative damage of nuclear membrane proteins and its prevention by vitamin C. Ghosh MK1, Arun R, Chattopadhyay DJ, Chatterjee IB.
  40. Cell Biol Toxicol. 2011 Dec;27(6):439-53. doi: 10.1007/s10565-011-9198-2. Epub 2011 Aug 18. Increased oxidative stress and cytotoxicity by hydrogen sulfide in HepG2 cells overexpressing cytochrome P450 2E1. Caro AA1, Thompson S, Tackett J
  41. Toxicol Appl Pharmacol. 2001 Mar 1;171(2):85-93. Polychlorinated biphenyl-induced effects on metabolic enzymes, AP-1 binding, vitamin E, and oxidative stress in the rat liver. Twaroski TP1, O'Brien ML, Larmonier N, Glauert HP, Robertson LW.
  42. Am J Pathol. 2005 Jun;166(6):1681-90. Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress. Zhou Z1, Wang L, Song Z, Saari JT, McClain CJ, Kang YJ.
  43. Biol Pharm Bull. 2013;36(7):1095-110. Sulphur antioxidants inhibit oxidative stress induced retinal ganglion cell death by scavenging reactive oxygen species but influence nuclear factor (erythroid-derived 2)-like 2 signalling pathway differently. Majid AS1, Yin ZQ, Ji D.
  44. J Physiol Biochem. 2010 Jun;66(2):143-51. doi: 10.1007/s13105-010-0019-5. Epub 2010 Jun 1. Protective effect of green tea on lead-induced oxidative damage in rat's blood and brain tissue homogenates. Hamed EA1, Meki AR, Abd El-Mottaleb NA.
  45. Mol Carcinog. 2007 Sep;46(9):797-806. Chemoprevention of rat mammary carcinogenesis by black tea polyphenols: modulation of xenobiotic-metabolizing enzymes, oxidative stress, cell proliferation, apoptosis, and angiogenesis. Kumaraguruparan R1, Seshagiri PB, Hara Y, Nagini S.
  46. Food Chem Toxicol. 2013 Sep;59:739-47. doi: 10.1016/j.fct.2013.07.032. Epub 2013 Jul 18. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Gao S1, Duan X, Wang X, Dong D, Liu D, Li X, Sun G, Li B.
  47. J Vet Med Sci. 2012 May;74(5):583-9. Epub 2011 Dec 19. Effects of oxidative stress caused by tert-butylhydroquinone on cytotoxicity in MDCK cells. Shibuya N1, Kobayashi S, Yoshikawa Y, Watanabe K, Orino K.
  48. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):395-403. Curcumin activates defensive genes and protects neurons against oxidative stress. Scapagnini G1, Colombrita C, Amadio M, D'Agata V, Arcelli E, Sapienza M, Quattrone A, Calabrese V.
  49. FASEB J. 2010 Oct;24(10):3733-43. doi: 10.1096/fj.09-152728. Epub 2010 May 21. Reactive oxygen species, oxidative stress, and cell death correlate with level of CoQ10 deficiency. Quinzii CM1, López LC, Gilkerson RW, Dorado B, Coku J, Naini AB, Lagier-Tourenne C, Schuelke M, Salviati L, Carrozzo R, Santorelli F, Rahman S, Tazir M, Koenig M, DiMauro S, Hirano M.
  50. Exp Neurol. 2001 Nov;172(1):211-9. Taurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy. Obrosova IG1, Fathallah L, Stevens MJ.
  51. Free Radic Res. 2010 Mar;44(3):340-55. doi: 10.3109/10715760903513017. Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. Das J1, Ghosh J, Manna P, Sil PC.
  52. Amino Acids. 2009 Mar;36(3):417-28. doi: 10.1007/s00726-008-0094-x. Epub 2008 Apr 15. Taurine plays a beneficial role against cadmium-induced oxidative renal dysfunction. Manna P1, Sinha M, Sil PC.
  53. Mol Nutr Food Res. 2014 Jan;58(1):211-5. doi: 10.1002/mnfr.201300282. Epub 2013 Nov 20. Investigation of the in vivo antioxidative activity of Cynara scolymus (artichoke) leaf extract in the streptozotocin-induced diabetic rat. Magielse J1, Verlaet A, Breynaert A, Keenoy BM, Apers S, Pieters L, Hermans N.
  54. Toxicol Appl Pharmacol. 1997 Jun;144(2):279-86. Antioxidative and protective properties of extracts from leaves of the artichoke (Cynara scolymus L.) against hydroperoxide-induced oxidative stress in cultured rat hepatocytes. Gebhardt R1.
  55. Lik Sprava. 2014 Jan-Feb;(1-2):140-5. Oxidative stress and antioxidant therapy with alpha-lipoic acid inclusion in acute poisoning by herbicide based on 2,4-dichlorphenoxyacetic acid. [Article in Ukrainian] Kharchenko OA, Balan HM, Bubalo NN, Mymrenko TV.
  56. Postepy Hig Med Dosw (Online). 2015 Mar 4;69:270-6. doi: 10.5604/17322693.1142473. Anti-oxidative and anti-inflammatory effects of lipoic acid in rat liver. Goraca A1, Huk-Kolega H1, Kowalczyk A1, Skibska B2.
  57. Food Chem Toxicol. 2013 Sep;59:339-55. doi: 10.1016/j.fct.2013.06.019. Epub 2013 Jun 20. Role of α-lipoic acid in dextran sulfate sodium-induced ulcerative colitis in mice: studies on inflammation, oxidative stress, DNA damage and fibrosis. Trivedi PP1, Jena GB.
  58. Altern Med Rev. 2006 Jun;11(2):114-27. Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity. Patrick L.
  59. Plant Foods Hum Nutr. 2010 Sep;65(3):193-9. doi: 10.1007/s11130-010-0182-4. Dietary broccoli sprouts protect against myocardial oxidative damage and cell death during ischemia-reperfusion. Akhlaghi M1, Bandy B.
  60. Free Radic Biol Med. 2010 Dec 1; 49(11): 1603–1616. Published online 2010 Sep 16. doi:  10.1016/j.freeradbiomed.2010.09.006 Oxidative stress, inflammation, and cancer: How are they linked? Simone Reuter, Subash C. Gupta, Madan M. Chaturvedi, and Bharat B. Aggarwal
  61. Nutr Cancer. 2002;43(1):103-10. Mutagenicity of food-derived carcinogens and the effect of antioxidant vitamins. Montgomery BA1, Murphy J, Chen JJ, Desai VG, McGarrity L, Morris SM, Casciano DA, Aidoo A.
  62. J Cancer Res Clin Oncol. 2011 Apr;137(4):677-86. doi: 10.1007/s00432-010-0926-4. Epub 2010 Jun 16. Chemopreventive effects of zinc on prostate carcinogenesis induced by N-methyl-N-nitrosourea and testosterone in adult male Sprague-Dawley rats. Banudevi S1, Elumalai P, Arunkumar R, Senthilkumar K, Gunadharini DN, Sharmila G, Arunakaran J.
  63. Toxicol In Vitro. 2006 Mar;20(2):187-210. Epub 2005 Nov 11. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Moon YJ1, Wang X, Morris ME.
  64. Carcinogenesis. 2008 May;29(5):1022-32. doi: 10.1093/carcin/bgn064. Epub 2008 Mar 4. Dietary curcumin modulates transcriptional regulators of phase I and phase II enzymes in benzo[a]pyrene-treated mice: mechanism of its anti-initiating action. Garg R1, Gupta S, Maru GB.
  65. Pharmacol Toxicol. 2003 Jan;92(1):33-8. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Iqbal M1, Sharma SD, Okazaki Y, Fujisawa M, Okada S.
  66. Int J Biochem Cell Biol. 1998 Apr;30(4):445-56. Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver. Piper JT1, Singhal SS, Salameh MS, Torman RT, Awasthi YC, Awasthi S.
  67. Mol Cell Biochem. 2013 May;377(1-2):163-76. doi: 10.1007/s11010-013-1582-1. Epub 2013 Feb 9. Dietary supplementation of silymarin is associated with decreased cell proliferation, increased apoptosis, and activation of detoxification system in hepatocellular carcinoma. Gopalakrishnan R1, Sundaram J, Sattu K, Pandi A, Thiruvengadam D.
  68. Int J Cancer. 2002 Oct 10;101(5):461-8. Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats. Kohno H1, Tanaka T, Kawabata K, Hirose Y, Sugie S, Tsuda H, Mori H.
  69. Carcinogenesis. 1999 Nov;20(11):2101-8. Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemoprevention. Zhao J1, Agarwal R.
  70. Carcinogenesis. 2003 Oct;24(10):1651-6. Epub 2003 Jul 17. Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens. van der Logt EM1, Roelofs HM, Nagengast FM, Peters WH.
  71. Free Radic Res. 2012 Jan;46(1):41-9. doi: 10.3109/10715762.2011.637204. Epub 2011 Nov 22. Quercetin suppresses cytochrome P450 mediated ROS generation and NFκB activation to inhibit the development of 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinomas. Priyadarsini RV1, Nagini S.
  72. Carcinogenesis. 1993 Jun;14(6):1221-3. Effects of anticarcinogenic monoterpenes on phase II hepatic metabolizing enzymes. Elegbede JA1, Maltzman TH, Elson CE, Gould MN.
  73. Carcinogenesis. 2003 Dec;24(12):1903-11. Epub 2003 Aug 29. Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes. Bacon JR1, Williamson G, Garner RC, Lappin G, Langouët S, Bao Y.
  74. Drug Chem Toxicol. 2015 Oct;38(4):442-51. doi: 10.3109/01480545.2014.992072. Epub 2015 Jan 22. Protective effects of silymarin on epirubicin-induced mucosal barrier injury of the gastrointestinal tract. Sasu A1, Herman H2, Mariasiu T3, Rosu M2, Balta C2, Anghel N3, Miutescu E4, Cotoraci C1, Hermenean A2,3.
  75. Biochim Biophys Acta. 1998 Mar 2;1379(3):325-36. Effects of the sulforaphane analog compound 30, indole-3-carbinol, D-limonene or relafen on glutathione S-transferases and glutathione peroxidase of the rat digestive tract. van Lieshout EM1, Posner GH, Woodard BT, Peters WH.
  76. Digestion. 1993;54(1):24-31. Role of nitric oxide and prostaglandins in gastroprotection induced by capsaicin and papaverine. Brzozowski T1, Drozdowicz D, Szlachcic A, Pytko-Polonczyk J, Majka J, Konturek SJ.
  77. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(10):1678-87. doi: 10.1080/19440049.2014.943304. Epub 2014 Aug 30. Probiotic lactic acid bacteria detoxify N-nitrosodimethylamine. Nowak A1, Kuberski S, Libudzisz Z.
  78. Curr Opin Biotechnol. 2010 Apr;21(2):157-67. doi: 10.1016/j.copbio.2010.03.016. Epub 2010 Apr 21. Interaction of probiotics and pathogens--benefits to human health? Salminen S1, Nybom S, Meriluoto J, Collado MC, Vesterlund S, El-Nezami H.
  79. Can J Microbiol. 2006 Sep;52(9):877-85. Probiotic bacteria as potential detoxification tools: assessing their heavy metal binding isotherms. Ibrahim F1, Halttunen T, Tahvonen R, Salminen S.
  80. Med Hypotheses. 2002 May;58(5):382-5. Probiotics as an adjuvant to detoxification protocols. Brudnak MA1.
  81. Am J Clin Nutr. 2001 Feb;73(2 Suppl):451S-455S. Protective role of probiotics and prebiotics in colon cancer. Wollowski I1, Rechkemmer G, Pool-Zobel BL.
  82. FASEB J. 2008 Feb;22(2):538-47. Epub 2007 Sep 20. Inflammation resolved by retinoid X receptor-mediated inactivation of leukotriene signaling pathways. Kalsotra A1, Du L, Wang Y, Ladd PA, Kikuta Y, Duvic M, Boyd AS, Keeney DS, Strobel HW.
  83. Inflammation. 2013 Oct;36(5):1111-21. doi: 10.1007/s10753-013-9645-8. Effect of methylsulfonylmethane on paraquat-induced acute lung and liver injury in mice. Amirshahrokhi K1, Bohlooli S.
  84. Cytokine. 2015 Feb;71(2):223-31. doi: 10.1016/j.cyto.2014.11.001. Epub 2014 Nov 21. Methylsulfonylmethane inhibits NLRP3 inflammasome activation. Ahn H1, Kim J1, Lee MJ1, Kim YJ2, Cho YW3, Lee GS4.
  85. Invest New Drugs. 2010 Oct;28(5):703-13. doi: 10.1007/s10637-009-9289-6. Epub 2009 Jul 10. Dietary supplementation of silymarin protects against chemically induced nephrotoxicity, inflammation and renal tumor promotion response. Kaur G1, Athar M, Alam MS.
  86. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4077-82. Epub 2007 Feb 27. Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway. Zhang WJ1, Wei H, Hagen T, Frei B.
  87. World J Gastroenterol. 2015 Sep 21;21(35):10091-103. doi: 10.3748/wjg.v21.i35.10091. Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury. Yoshida K1, Ushida Y1, Ishijima T1, Suganuma H1, Inakuma T1, Yajima N1, Abe K1, Nakai Y1.
  88. Chem Biol Interact. 2007 Jan 30;165(2):146-54. Epub 2006 Dec 2. Hepatocyte susceptibility to glyoxal is dependent on cell thiamin content. Shangari N1, Mehta R, O'brien PJ.
  89. Am J Physiol Endocrinol Metab. 2016 Jan 19:ajpendo.00260.2015. doi: 10.1152/ajpendo.00260.2015. [Epub ahead of print] Changes in one-carbon metabolism after duodenal-jejunal bypass surgery. Jung J1, Ha TK2, Lee J3, Lho Y4, Nam M3, Lee D3, le Roux CW5, Ryu DH6, Ha E4, Hwang GS7.
  90. Toxicology. 2001 Aug 28;165(2-3):217-24. Carbon tetrachloride-induced changes in the activity of phase II drug-metabolizing enzyme in the liver of male rats: role of antioxidants. Sheweita SA1, Abd El-Gabar M, Bastawy M.
  91. Hum Exp Toxicol. 2003 Mar;22(3):129-36. Protective role of ascorbic acid and alpha-tocopherol on arsenic-induced microsomal dysfunctions. Ramanathan K1, Shila S, Kumaran S, Panneerselvam C.
  92. Altern Med Rev. 1998 Apr;3(2):114-27. Clinical applications of N-acetylcysteine. Kelly GS1.
  93. Chem Biol Interact. 2013 Jan 25;201(1-3):9-18. doi: 10.1016/j.cbi.2012.10.027. Epub 2012 Nov 16. Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats. Ahmad I1, Shukla S, Kumar A, Singh BK, Kumar V, Chauhan AK, Singh D, Pandey HP, Singh C.
  94. Food Chem Toxicol. 2012 Dec;50(12):4375-81. doi: 10.1016/j.fct.2012.08.045. Epub 2012 Aug 30. Modulation of CYP1A1, CYP1B1 and DNA adducts level by green and white tea in Balb/c mice. Kumar M1, Jain M, Sehgal A, Sharma VL.
  95. Food Chem Toxicol. 2008 Apr;46(4):1271-8. Epub 2007 Oct 17. Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG. Na HK1, Surh YJ.
  96. Toxicol Lett. 2007 May 15;170(3):238-47. Epub 2007 Mar 24. Curcumin activates human glutathione S-transferase P1 expression through antioxidant response element. Nishinaka T1, Ichijo Y, Ito M, Kimura M, Katsuyama M, Iwata K, Miura T, Terada T, Yabe-Nishimura C.
  97. Pharmacol Rep. 2014 Feb;66(1):87-92. doi: 10.1016/j.pharep.2013.08.009. Epub 2014 Feb 1. The effect of lipoic acid on cyanate toxicity in the rat heart. Sokołowska M1, Kostański M2, Lorenc-Koci E3, Bilska A2, Iciek M2, Włodek L2.
  98. Br J Nutr. 2014 Aug 14;112(3):295-308. doi: 10.1017/S0007114514000841. Epub 2014 Apr 30. Effect of dietary α-lipoic acid on the mRNA expression of genes involved in drug metabolism and antioxidation system in rat liver. Ide T1.
  99. Biochim Biophys Acta. 2009 Oct;1790(10):1149-60. doi: 10.1016/j.bbagen.2009.07.026. Epub 2009 Aug 4. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Shay KP1, Moreau RF, Smith EJ, Smith AR, Hagen TM.
  100. Int J Oncol. 2008 Oct;33(4):833-8. Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by alpha-lipoic acid in human leukemia HL-60 cells. Elangovan S1, Hsieh TC.
  101. Toxicol Appl Pharmacol. 2015 Jan 1;282(1):52-60. doi: 10.1016/j.taap.2014.11.004. Epub 2014 Nov 18. Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1. Techapiesancharoenkij N1, Fiala JL2, Navasumrit P1, Croy RG2, Wogan GN2, Groopman JD3, Ruchirawat M1, Essigmann JM4.
  102. J Food Sci. 2011 Sep;76(7):H175-81. doi: 10.1111/j.1750-3841.2011.02311.x. Epub 2011 Aug 22. Cruciferous vegetable phytochemical sulforaphane affects phase II enzyme expression and activity in rat cardiomyocytes through modulation of Akt signaling pathway. Leoncini E1, Malaguti M, Angeloni C, Motori E, Fabbri D, Hrelia S.
  103. J Agric Food Chem. 2004 Apr 7;52(7):1867-71. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds. Munday R1, Munday CM.
  104. J Environ Manage. 2008 Apr;87(1):46-58. Epub 2007 May 11. Immobilization of Pb(II), Cd(II) and Ni(II) ions on kaolinite and montmorillonite surfaces from aqueous medium. Sen Gupta S1, Bhattacharyya KG.
  105. J Environ Sci Eng. 2013 Jul;55(3):371-6. Accumulation of heavy metals (Cu, Cr, Pb and Cd) in freshwater micro algae (Chlorella sp.). Kumar RM, Frankilin J, Raj SP.
  106. Bioresour Technol. 2013 May;136:604-9. doi: 10.1016/j.biortech.2013.03.043. Epub 2013 Mar 15. Chromate tolerance and accumulation in Chlorella vulgaris L.: role of antioxidant enzymes and biochemical changes in detoxification of metals. Rai UN1, Singh NK, Upadhyay AK, Verma S.
  107. Vopr Pitan. 2014;83(3):4-11. Effects of vitamins deficiency on the cytochrome P450 inducibility in rats. [Article in Russian] Trusov NV, Guseva GV, Beketova NA, Aksenov IV, Avrent'eva LI, Kravchenko LV.
  108. Int J Vitam Nutr Res. 2013;83(1):5-13. doi: 10.1024/0300-9831/a000140. Activity of xenobiotic-metabolizing enzymes in the liver of rats with multi-vitamin deficiency. Tutelyan VA1, Kravchenko LV, Aksenov IV, Trusov NV, Guseva GV, Kodentsova VM, Vrzhesinskaya OA, Beketova NA
  109. Ukr Biokhim Zh (1999). 2012 Mar-Apr;84(2):42-7. Activity of enzymatic detoxification systems in the mice liver under conditions of different retinoid provision. [Article in Ukrainian] Marchenko MM, Kopyl'chuk HP, Shmarakov IO, Buchkovs'ka IM
  110. Eur J Clin Nutr. 2001 Nov;55(11):1022-7. Serum vitamin E, C and A status of the drug addicts undergoing detoxification: influence of drug habit, sexual practice and lifestyle factors. Nazrul Islam SK1, Jahangir Hossain K, Ahsan M.
  111. Br J Nutr. 2001 Mar;85(3):289-97. Influence of vitamin A status on the regulation of uridine (5'-)diphosphate-glucuronosyltransferase (UGT) 1A1 and UGT1A6 expression by L-triiodothyronine. Haberkorn V1, Heydel JM, Mounie J, Artur Y, Goudonnet H.
  112. Drug Metab Dispos. 2000 Oct;28(10):1210-6. Glucuronidation of estrogens and retinoic acid and expression of UDP-glucuronosyltransferase 2B7 in human intestinal mucosa. Czernik PJ1, Little JM, Barone GW, Raufman JP, Radominska-Pandya A.
  113. Biochem Pharmacol. 1994 Jul 5;48(1):139-44. The distribution of non-specific carboxylesterases and glutathione S-transferases in different rat liver cells. Effects of vitamin A deficiency. Gad MZ1.
  114. Alcohol Alcohol. 1996 Sep;31(5):493-501. Thiamine pyrophosphate effect and normalized erythrocyte transketolase activity ratio in Wernicke-Korsakoff patients and acute alcoholics undergoing detoxification. Rooprai HK1, Pratt OE, Shaw GK, Thomson AD.
  115. Biochem Pharmacol. 1990 Feb 1;39(3):519-25. Effects of thiamine deficiency on hepatic cytochromes P450 and drug-metabolizing enzyme activities. Yoo JS1, Park HS, Ning SM, Lee MJ, Yang CS
  116. Toxicol Sci. 2011 Aug;122(2):502-11. doi: 10.1093/toxsci/kfr102. Epub 2011 May 6. 1,3-Dinitrobenzene-induced metabolic impairment through selective inactivation of the pyruvate dehydrogenase complex. Miller JA1, Runkle SA, Tjalkens RB, Philbert MA.
  117. Int Immunopharmacol. 2014 Aug;21(2):383-8. doi: 10.1016/j.intimp.2014.05.014. Epub 2014 May 27. Carbon tetrachloride-induced hepatotoxicity in rat is reversed by treatment with riboflavin. Al-Harbi NO1, Imam F2, Nadeem A1, Al-Harbi MM1, Iqbal M3, Ahmad SF1.
  118. Regul Toxicol Pharmacol. 2013 Dec;67(3):434-45. doi: 10.1016/j.yrtph.2013.09.002. Epub 2013 Sep 10. Influence of mitochondrion-toxic agents on the cardiovascular system. Finsterer J1, Ohnsorge P.
  119. Ann Pharm Fr. 2011 Jan;69(1):45-52. doi: 10.1016/j.pharma.2010.10.004. Epub 2010 Dec 28. FAD-dependent enzymes involved in the metabolic oxidation of xenobiotics. Strolin Benedetti M1.
  120. Altern Med Rev. 1998 Jun;3(3):187-98. The detoxification enzyme systems. Liska DJ1.
  121. Biochem Soc Trans. 2000;28(4):283-96. The chemical and biological versatility of riboflavin. Massey V1.
  122. Atherosclerosis. 2009 Jun;204(2):412-7. doi: 10.1016/j.atherosclerosis.2008.09.015. Epub 2008 Sep 27. Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine. Riederer M1, Erwa W, Zimmermann R, Frank S, Zechner R.
  123. Med Hypotheses. 1982 Sep;9(3):265-82. Evaluation of a detoxification regimen for fat stored xenobiotics. Schnare DW, Denk G, Shields M, Brunton S.
  124. Structure. 2013 Sep 3;21(9):1581-9. doi: 10.1016/j.str.2013.06.022. Epub 2013 Aug 1. Redox-linked domain movements in the catalytic cycle of cytochrome p450 reductase. Huang WC1, Ellis J, Moody PC, Raven EL, Roberts GC.
  125. Biomed Khim. 2011 May-Jun;57(3):343-54. The influence of vitamin B group on monooxygenase activity of cytochrome P450 3A4: pharmacokinetics and electro analysis of catalytic properties. [Article in Russian] Shumiantseva VV, Shikh EV, Makhova AA, Bylko TV, Kukes VG, Sizova OS, Ramenskaia GV, Usanov SA, Archakov AI.
  126. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13486-91. doi: 10.1073/pnas.1106632108. Epub 2011 Aug 1. Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency. Xia C1, Panda SP, Marohnic CC, Martásek P, Masters BS, Kim JJ.
  127. Expert Opin Drug Metab Toxicol. 2008 Jun;4(6):697-720. doi: 10.1517/17425255.4.6.697 . Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily. Marchitti SA1, Brocker C, Stagos D, Vasiliou V.
  128. J Immunotoxicol. 2009 Sep;6(3):147-60. doi: 10.1080/15476910903083866. The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in B6C3F1 mice. Tangjarukij C1, Navasumrit P, Zelikoff JT, Ruchirawat M.
  129. J Am Coll Nutr. 1991 Dec;10(6):602-32. Alcohol, liver, and nutrition. Lieber CS1.
  130. Theor Biol Med Model. 2011 Aug 26;8:31. doi: 10.1186/1742-4682-8-31. Mathematical model insights into arsenic detoxification. Lawley SD1, Cinderella M, Hall MN, Gamble MV, Nijhout HF, Reed MC.
  131. J Headache Pain. 2005 Sep;6(4):334-7. Preliminary results of a withdrawal and detoxification therapeutic regimen in patients with probable chronic migraine and probable medication overuse headache. Trucco M1, Meineri P, Ruiz L; "Gruppo Neurologico Ospedaliero Interregionale per lo Studio delle Cefalee" (Neurological Hospital Interregional Group for the Study of Headache).
  132. J Cell Biochem Suppl. 1994;20:1-24. Mechanistic considerations in chemopreventive drug development. Kelloff GJ1, Boone CW, Steele VE, Fay JR, Lubet RA, Crowell JA, Sigman CC.
  133. Exp Biol Med (Maywood). 2006 May;231(5):641-9. Cyanide detoxification by the cobalamin precursor cobinamide. Broderick KE1, Potluri P, Zhuang S, Scheffler IE, Sharma VS, Pilz RB, Boss GR.
  134. Fundam Appl Toxicol. 1983 Sep-Oct;3(5):397-9. Cyanide in human disease: a review of clinical and laboratory evidence. Wilson J.
  135. J Biol Chem. 1998 Oct 2;273(40):26248-55. Purification of soluble cytochrome b5 as a component of the reductive activation of porcine methionine synthase. Chen Z1, Banerjee R.
  136. Mutat Res. 2014 Dec;770:37-44. doi: 10.1016/j.mrfmmm.2014.09.008. Epub 2014 Sep 27. Human CYP2E1-dependent and human sulfotransferase 1A1-modulated induction of micronuclei by benzene and its hydroxylated metabolites in Chinese hamster V79-derived cells. Jiang H1, Lai Y1, Hu K1, Wei Q1, Liu Y2.
  137. Chem Biol Interact. 2013 Feb 25;202(1-3):259-66. doi: 10.1016/j.cbi.2012.11.017. Epub 2012 Dec 7. Acrolein and chloroacetaldehyde: an examination of the cell and cell-free biomarkers of toxicity. MacAllister SL1, Martin-Brisac N, Lau V, Yang K, O'Brien PJ.
  138. Animal. 2013 Apr;7(4):591-601. doi: 10.1017/S1751731112002054. Epub 2012 Nov 26. The detoxication of nitrate by two antioxidants or a probiotic, and the effects on blood and seminal plasma profiles and reproductive function of New Zealand White rabbit bucks. Attia YA1, Abd El Hamid EA, Ismaiel AM, El-Nagar A.
  139. Environ Int. 2012 Sep 15;45:1-8. doi: 10.1016/j.envint.2012.04.002. Epub 2012 May 5. Dietary benzo(a)pyrene and fetal growth: effect modification by vitamin C intake and glutathione S-transferase P1 polymorphism. Duarte-Salles T1, Mendez MA, Morales E, Bustamante M, Rodríguez-Vicente A, Kogevinas M, Sunyer J.
  140. Chem Res Toxicol. 2009 May;22(5):863-74. doi: 10.1021/tx900042u. Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells. Miranda CL1, Reed RL, Kuiper HC, Alber S, Stevens JF.
  141. Cancer Lett. 2007 Feb 8;246(1-2):54-62. Epub 2006 Mar 6. Ascorbic acid differentially modulates the induction of heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase Ya by As(3+), Cd(2+) and Cr(6+). Elbekai RH1, Duke J, El-Kadi AO.
  142. Toxicology. 2005 Nov 5;215(1-2):97-107. Epub 2005 Aug 10. Aluminium-induced deterioration in reproductive performance and seminal plasma biochemistry of male rabbits: protective role of ascorbic acid. Yousef MI1, El-Morsy AM, Hassan MS.
  143. Malays J Nutr. 2004 Mar;10(1):39-51. Epub 2004 Mar 15. Health perspective of pesticide exposure and dietary management. Xavier R Jr1, Rekha K, Bairy K.
  144. Int J Toxicol. 2002 Sep-Oct;21(5):419-24. Can nutrition affect chemical toxicity? Furst A1.
  145. Toxicol In Vitro. 1999 Dec;13(6):879-87. Chromium (VI)-induced cytotoxicity to osteoblast-derived cells. Ning J1, Grant MH.
  146. Int J Vitam Nutr Res. 1998;68(1):42-7. Modulation of drug metabolizing enzymes in guinea pig liver by high intakes of ascorbic acid. Roomi MW1, Netke S, Tsao C.
  147. Food Chem Toxicol. 1993 Jun;31(6):435-7. Effect of ascorbic acid in the detoxification of the insecticide dimethoate in the bone marrow erythrocytes of mice. Geetanjali D1, Rita P, Reddy PP.
  148. J Biomed Mater Res A. 2012 Feb;100(2):462-9. doi: 10.1002/jbm.a.33287. Epub 2011 Nov 29. Biotransformation enzymes and lung cell response to 2-hydroxyethyl-methacrylate. Samuelsen JT1, Holme JA, Låg M, Schwarze PE, Dahl JE, Becher R.
  149. Chem Res Toxicol. 2011 May 16;24(5):677-86. doi: 10.1021/tx1004375. Epub 2011 Mar 11. Novel cytochrome p450 bioactivation of a terminal phenyl acetylene group: formation of a one-carbon loss benzaldehyde and other oxidative products in the presence of N-acetyl cysteine or glutathione. Subramanian R1, Tam J, Aidasani D, Reid DL, Skiles GL.
  150. Eur J Pharmacol. 2006 Mar 18;534(1-3):202-9. Epub 2006 Feb 17. Vitamins C and E protect hepatic cytochrome P450 dysfunction induced by polymicrobial sepsis. Kim JY1, Lee SM.
  151. Mol Cell Endocrinol. 2004 Jun 30;221(1-2):57-66. Effect of ascorbic acid supplementation on testicular steroidogenesis and germ cell death in cadmium-treated male rats. Sen Gupta R1, Kim J, Gomes C, Oh S, Park J, Im WB, Seong JY, Ahn RS, Kwon HB, Soh J.
  152. J Nutr Sci Vitaminol (Tokyo). 2000 Jun;46(3):137-40. Effect of oxidized frying oil and vitamin C levels on the hepatic xenobiotic-metabolizing enzyme system of guinea pigs. Liu JF1, Lee YW, Chang FC.
  153. Chem Biol Interact. 2015 Sep 5;239:67-75. doi: 10.1016/j.cbi.2015.06.022. Epub 2015 Jun 20. Effect of tetrahydrocurcumin on the profiles of drug-metabolizing enzymes induced by a high fat and high fructose diet in mice. Jearapong N1, Chatuphonprasert W2, Jarukamjorn K3.
  154. J Environ Sci Eng. 2012 Jul;54(3):441-6. Role of antioxidants in detoxification of Cr (VI) toxicity in laboratory rats. Kumar D, Gangwar SP.
  155. Int J Toxicol. 2007 Jul-Aug;26(4):297-306. Vitamin E protection from testicular damage caused by intraperitoneal aluminium. Kutlubay R1, Oğuz EO, Can B, Güven MC, Sinik Z, Tuncay OL.
  156. Toxicology. 2002 Nov 15;180(2):195-207. Dietary vitamin E and selenium and toxicity of nitrite and nitrate. Chow CK1, Hong CB.
  157. J Pharm Pharm Sci. 2000 Sep-Dec;3(3):281-91. Significance of apoptosis and its relationship to antioxidants after ochratoxin A administration in mice. Atroshi F1, Biese I, Saloniemi H, Ali-Vehmas T, Saari S, Rizzo A, Veijalainen P.
  158. Nutr Cancer. 1998;32(1):37-42. alpha-Tocopherol acetate supplementation enhances rat hepatic cytochrome PROD activity in the presence of phenobarbital induction. Lii CK1, Sung WC, Ko YJ, Chen HW.
  159. Analyst. 1998 Jan;123(1):3-6. Rheumatoid arthritis and metal compounds--perspectives on the role of oxygen radical detoxification. Aaseth J1, Haugen M, Førre O.
  160. Cancer Lett. 1997 Nov 11;119(2):201-6. Postnatal efficacy of antioxidants in the detoxification pathway of suckling neonates and lactating mice. Singh A1, Singh SP, Bamezai R.
  161. Drug Chem Toxicol. 2015 Oct 8:1-8. [Epub ahead of print] The ameliorating effects of vitamin E on hepatic antioxidant system and xenobiotic-metabolizing enzymes in fenvalerate-exposed iodine-deficient rats. Kocer-Gumusel B1, Erkekoglu P1, Caglayan A1, Hincal F1.
  162. Bull Exp Biol Med. 2013 Mar;154(5):638-41. Cold-induced activities of cytochromes P450 1A1 and 1A2 in rat liver: putative role of endogenous compounds in induction mechanism. Perepechaeva ML1, Grishanova AY.
  163. Drug Metab Dispos. 2013 Feb;41(2):406-13. doi: 10.1124/dmd.112.048009. Epub 2012 Nov 16. Cytochrome P450 regulation by α-tocopherol in Pxr-null and PXR-humanized mice. Johnson CH1, Bonzo JA, Cheng J, Krausz KW, Kang DW, Luecke H, Idle JR, Gonzalez FJ.
  164. Free Radic Biol Med. 2011 Dec 1;51(11):2031-40. doi: 10.1016/j.freeradbiomed.2011.08.033. Epub 2011 Sep 3. α-Tocopherol injections in rats up-regulate hepatic ABC transporters, but not cytochrome P450 enzymes. Traber MG1, Labut EM, Leonard SW, Lebold KM.
  165. J Appl Toxicol. 2011 Mar;31(2):173-8. doi: 10.1002/jat.1578. Epub 2010 Aug 30. Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats. Ishihara Y1, Ishii S, Sakai Y, Yamamura N, Onishi Y, Shimamoto N.
  166. J Nutr Biochem. 2009 Jun;20(6):469-76. doi: 10.1016/j.jnutbio.2008.05.007. Epub 2008 Sep 11. Alpha-tocopherol modulates genes involved in hepatic xenobiotic pathways in mice. Mustacich DJ1, Gohil K, Bruno RS, Yan M, Leonard SW, Ho E, Cross CE, Traber MG.
  167. Free Radic Biol Med. 2006 Oct 1;41(7):1069-78. Epub 2006 Jul 4. Alpha-tocopherol regulation of hepatic cytochrome P450s and ABC transporters in rats. Mustacich DJ1, Leonard SW, Devereaux MW, Sokol RJ, Traber MG.
  168. J Environ Pathol Toxicol Oncol. 2000;19(4):401-13. Antimutagenesis studies of magnesium and calcium salts. Bronzetti G1, Aretini P, Ambrosini C, Cini M, Fiorio R, Caltavuturo L, Croce CD, Panunzio M.
  169. Am J Clin Nutr. 1995 Mar;61(3 Suppl):651S-658S. Influence of nutrients and other dietary materials on cytochrome P-450 enzymes. Guengerich FP1.
  170. Biol Trace Elem Res. 2014 May;158(2):243-8. doi: 10.1007/s12011-014-9915-9. Epub 2014 Mar 6. The effect of copper on the mRNA expression profile of xenobiotic-metabolizing enzymes in cultured rat H4-II-E cells. Darwish WS1, Ikenaka Y, Nakayama S, Ishizuka M.
  171. Toxicol In Vitro. 2008 Feb;22(1):154-8. Epub 2007 Aug 17. Modulation of TCDD-mediated induction of cytochrome P450 1A1 by mercury, lead, and copper in human HepG2 cell line. Korashy HM1, El-Kadi AO.
  172. Exp Biol Med (Maywood). 2006 May;231(5):545-52. Double null of selenium-glutathione peroxidase-1 and copper, zinc-superoxide dismutase enhances resistance of mouse primary hepatocytes to acetaminophen toxicity. Zhu JH1, Lei XG.
  173. J Environ Sci Health B. 2005;40(5):769-84. Pesticides and essential minerals modify endogenous antioxidants and cytochrome P450 in tissues of rats. Bebe FN1, Panemangalore M.
  174. Eur J Pharmacol. 2001 Feb 2;412(3):281-9. Role of copper ions and cytochrome P450 in the vasodilator actions of the nitroxyl anion generator, Angeli's salt, on rat aorta. Nelli S1, McIntosh L, Martin W.
  175. Indian J Exp Biol. 1999 Feb;37(2):109-16. Role of nutrition in toxic injury. Lall SB1, Singh B, Gulati K, Seth SD.
  176. Nat Chem. 2015 Sep;7(9):696-702. doi: 10.1038/nchem.2306. Epub 2015 Aug 3. Significantly shorter Fe-S bond in cytochrome P450-I is consistent with greater reactivity relative to chloroperoxidase. Krest CM1, Silakov A1, Rittle J1, Yosca TH1, Onderko EL1, Calixto JC1, Green MT1.
  177. Adv Exp Med Biol. 2015;851:299-317. doi: 10.1007/978-3-319-16009-2_11. Biological diversity of cytochrome P450 redox partner systems. McLean KJ1, Luciakova D, Belcher J, Tee KL, Munro AW.
  178. Adv Exp Med Biol. 2015;851:63-81. doi: 10.1007/978-3-319-16009-2_2. Oxidizing intermediates in P450 catalysis: a case for multiple oxidants. Modi AR1, Dawson JH.
  179. Adv Exp Med Biol. 2015;851:1-61. doi: 10.1007/978-3-319-16009-2_1. Monooxygenase, peroxidase and peroxygenase properties and reaction mechanisms of cytochrome P450 enzymes. Hrycay EG1, Bandiera SM.
  180. J Chem Theory Comput. 2013 Jun 11;9(6):2519-25. doi: 10.1021/ct400190f. Epub 2013 May 8. The Fe(III)(H2O2) Complex as a Highly Efficient Oxidant in Sulfoxidation Reactions: Revival of an Underrated Oxidant in Cytochrome P450. Wang B1, Li C1, Cho KB2, Nam W2, Shaik S1.
  181. J Biol Chem. 2013 Jun 14;288(24):17065-73. doi: 10.1074/jbc.R113.462275. Epub 2013 Apr 30. Unusual cytochrome p450 enzymes and reactions. Guengerich FP1, Munro AW.
  182. Environ Toxicol Pharmacol. 2008 Mar;25(2):197-201. doi: 10.1016/j.etap.2007.10.016. Zinc nutritional status modulates expression of ahr-responsive p450 enzymes in vascular endothelial cells.Shen H1, Arzuaga X, Toborek M, Hennig B.
  183. J Nutr Biochem. 2007 Aug;18(8):509-18. Epub 2006 Dec 4. Dietary zinc restriction in rats alters antioxidant status and increases plasma F2 isoprostanes. Bruno RS1, Song Y, Leonard SW, Mustacich DJ, Taylor AW, Traber MG, Ho E.
  184. Drug Metab Pharmacokinet. 2006 Jun;21(3):201-7. Activities of rat cytochrome P450 3A and 2C isoforms are increased in vivo by magnesium sulfate as evidenced by enhanced oxidation of bupivacaine and testosterone in liver microsomes. Saito M1, Okutomi T, Shimizu M, Matsumoto Y, Yamazaki H, Hoka S.
  185. J Environ Pathol Toxicol Oncol. 2015;34(1):23-34. Lead acetate-induced hepatoxicity in Wistar rats: possible protective role of combination therapy. Sharma S1, Raghuvanshi S1, Jaswal A1, Shrivastava S1, Shukla S2.
  186. Environ Sci Pollut Res Int. 2014 May;21(10):6384-99. doi: 10.1007/s11356-013-1690-1. Epub 2013 May 4. Dietary antioxidants (selenium and N-acetylcysteine) modulate paraoxonase 1 (PON1) in PCB 126-exposed rats. Shen H1, Li M, Wang B, Lai IK, Robertson LW, Ludewig G.
  187. J Biol Inorg Chem. 2015 Mar;20(2):265-75. doi: 10.1007/s00775-014-1216-4. Epub 2014 Nov 26. The mammalian molybdenum enzymes of mARC. Ott G1, Havemeyer A, Clement B.
  188. Drug Metab Dispos. 2013 Dec;41(12):2175-86. doi: 10.1124/dmd.113.054635. Epub 2013 Sep 30. RNA-sequencing quantification of hepatic ontogeny of phase-I enzymes in mice. Peng L1, Cui JY, Yoo B, Gunewardena SS, Lu H, Klaassen CD, Zhong XB.
  189. J Med Chem. 2008 Dec 25;51(24):8173-7. doi: 10.1021/jm8010417. The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs. Gruenewald S1, Wahl B, Bittner F, Hungeling H, Kanzow S, Kotthaus J, Schwering U, Mendel RR, Clement B.
  190. Chem Biodivers. 2007 Mar;4(3):257-405. The biochemistry of drug metabolism--an introduction: Part 2. Redox reactions and their enzymes. Testa B1, Krämer SD.
  191. Curr Drug Metab. 2000 Dec;1(4):357-89. The biotransformation of nitrogen containing xenobiotics to lactams. Vickers S1, Polsky SL.
  192. Cancer Prev Res (Phila). 2016 Feb;9(2):189-95. doi: 10.1158/1940-6207.CAPR-15-0069. Epub 2015 Dec 8. Phase II Drug-Metabolizing Polymorphisms and Smoking Predict Recurrence of Non-Muscle-Invasive Bladder Cancer: A Gene-Smoking Interaction. Lacombe L1, Fradet V2, Lévesque É3, Pouliot F2, Larue H2, Bergeron A2, Hovington H4, Caron A4, Nguile-Makao M4, Harvey M5, Fradet Y2, Guillemette C5.
  193. Drug Metab Dispos. 2016 Feb;44(2):262-74. doi: 10.1124/dmd.115.067504. Epub 2015 Nov 19. Regulation of Hepatic Drug-Metabolizing Enzymes in Germ-Free Mice by Conventionalization and Probiotics. Selwyn FP1, Cheng SL1, Klaassen CD1, Cui JY2.
  194. Toxicol Appl Pharmacol. 2015 Nov 15;289(1):1-11. doi: 10.1016/j.taap.2015.08.017. Epub 2015 Sep 1. Taurine zinc solid dispersions attenuate doxorubicin-induced hepatotoxicity and cardiotoxicity in rats. Wang Y1, Mei X1, Yuan J1, Lu W1, Li B1, Xu D2.
  195. Chem Res Toxicol. 2014 Dec 15;27(12):2071-81. doi: 10.1021/tx500288b. Epub 2014 Nov 18. Cytochrome P450-mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases. Venkataraman H1, den Braver MW, Vermeulen NP, Commandeur JN.
  196. Environ Mol Mutagen. 2014 Apr;55(3):184-95. doi: 10.1002/em.21823. Epub 2013 Nov 9. Bisphenol A-associated alterations in the expression and epigenetic regulation of genes encoding xenobiotic metabolizing enzymes in human fetal liver. Nahar MS1, Kim JH, Sartor MA, Dolinoy DC.
  197. Food Chem. 2013 Sep 1;140(1-2):1-8. doi: 10.1016/j.foodchem.2013.02.073. Epub 2013 Feb 26. Glutathione conjugation attenuates biological activities of 6-dehydroshogaol from ginger. Zhang G1, Nitteranon V, Chan LY, Parkin KL.
  198. Arch Toxicol. 2013 Feb;87(2):269-80. doi: 10.1007/s00204-012-0917-0. Epub 2012 Aug 17. Multidrug resistance-associated proteins are involved in the transport of the glutathione conjugates of the ultimate carcinogen of benzo[a]pyrene in human Caco-2 cells. Hessel S1, John A, Seidel A, Lampen A.
  199. Free Radic Biol Med. 2014 May;70:78-85. doi: 10.1016/j.freeradbiomed.2014.02.008. Epub 2014 Feb 18. Glutathionylated 4-hydroxy-2-(E)-alkenal enantiomers in rat organs and their contributions toward the disposal of 4-hydroxy-2-(E)-nonenal in rat liver. Sadhukhan S1, Han Y1, Jin Z2, Tochtrop GP3, Zhang GF4.
  200. PLoS One. 2015 Aug 14;10(8):e0135815. doi: 10.1371/journal.pone.0135815. eCollection 2015. N-Acetyl Cysteine (NAC)-Directed Detoxification of Methacryloxylethyl Cetyl Ammonium Chloride (DMAE-CB). Jiao Y1, Ma S1, Li J2, Shan L3, Wang Y4, Tian M1, Yang Y1, Sun J1, Ban J1, Chen J1.
  201. Dent Mater. 2013 Dec;29(12):1219-27. doi: 10.1016/j.dental.2013.09.008. Epub 2013 Oct 11. Mechanism of detoxification of the cationic antibacterial monomer 12-methacryloyloxydodecylpyridiniumbromide (MDPB) by N-acetyl cysteine. Ma S1, Imazato S, Takahashi Y, Kiba W, Takeda K, Izutani N, Kitagawa H, Chen J.
  202. Exp Toxicol Pathol. 2012 Jan;64(1-2):103-8. doi: 10.1016/j.etp.2010.07.001. Epub 2010 Aug 4. Therapeutic potential of N-acetyl cysteine with antioxidants (Zn and Se) supplementation against dimethylmercury toxicity in male albino rats. Joshi D1, Mittal DK, Shukla S, Srivastav AK.
  203. Anal Bioanal Chem. 2009 Nov;395(6):1929-35. doi: 10.1007/s00216-009-3105-1. Detoxification of mercury species--an in vitro study with antidotes in human whole blood. Trümpler S1, Nowak S, Meermann B, Wiesmüller GA, Buscher W, Sperling M, Karst U.
  204. Exp Neurol. 2008 Apr;210(2):560-76. doi: 10.1016/j.expneurol.2007.12.011. Epub 2007 Dec 23. Lipopolysaccharide-induced peroxisomal dysfunction exacerbates cerebral white matter injury: attenuation by N-acetyl cysteine. Paintlia MK1, Paintlia AS, Contreras MA, Singh I, Singh AK.
  205. Clin Exp Med. 2004 Sep;4(1):50-5. N-acetyl cysteine, L-cysteine, and beta-mercaptoethanol augment selenium-glutathione peroxidase activity in glucose-6-phosphate dehydrogenase-deficient human erythrocytes. Alicigüzel Y1, Aslan M.
  206. Cell Mol Life Sci. 2003 Jan;60(1):6-20. Molecular mechanisms of N-acetylcysteine actions. Zafarullah M1, Li WQ, Sylvester J, Ahmad M.
  207. J Cell Biochem Suppl. 1995;22:33-41. Chemopreventive properties and mechanisms of N-Acetylcysteine. The experimental background. De Flora S1, Cesarone CF, Balansky RM, Albini A, D'Agostini F, Bennicelli C, Bagnasco M, Camoirano A, Scatolini L, Rovida A, et al.
  208. Electron Physician. 2015 Oct 19;7(6):1310-7. doi: 10.14661/1310. eCollection 2015. Comparing the Therapeutic Effectiveness of N-acetylcysteine with the Combination of N-acetyl Cysteine and Cimetidine in Acute Acetaminophen Toxicity: A Double-Blinded Clinical Trial. Ebrahimi M1, Mousavi SR2, Toussi AG3, Reihani H1, Bagherian F4.
  209. Toxicol In Vitro. 2009 Oct;23(7):1259-67. doi: 10.1016/j.tiv.2009.07.027. Epub 2009 Jul 30. Regulation of CYP4A expression by bezafibrate in primary culture of rat and human hepatocytes: interspecies difference and influence of N-acetylcysteine. Alvergnas M1, Richert L, Blanchard N, Abadie C, Heyd B, Mantion G, Gallemann D, Martin H.
  210. Toxicol Appl Pharmacol. 2006 Jul 15;214(2):109-17. Epub 2006 Jan 20. Enhancement of DMNQ-induced hepatocyte toxicity by cytochrome P450 inhibition. Ishihara Y1, Shiba D, Shimamoto N.
  211. Drug Metab Dispos. 2003 Dec;31(12):1499-506. Acetaminophen-induced hepatotoxicity. James LP1, Mayeux PR, Hinson JA.
  212. Indian J Exp Biol. 2001 May;39(5):436-40. Protective effect of N-acetylcysteine in isoniazid induced hepatic injury in growing rats. Attri S1, Rana SV, Vaiphie K, Katyal R, Sodhi CP, Kanwar S, Singh K.
  213. J Sports Med Phys Fitness. 2012 Apr;52(2):170-4. Effect of methylsulfonylmethane supplementation on exercise - Induced muscle damage and total antioxidant capacity. Barmaki S1, Bohlooli S, Khoshkhahesh F, Nakhostin-Roohi B.
  214. Adv Biomed Res. 2015 Jul 27;4:155. doi: 10.4103/2277-9175.161582. eCollection 2015. Survey of the detoxification effect of green tea extract on the reproductive system in rats exposed to lead acetate. Sha'bani N1, Miraj S2, Rafieian-Kohpayei M3, Namjoo AR4.
  215. Environ Sci Pollut Res Int. 2015 Aug 28. [Epub ahead of print] Detoxification effects of phytonutrients against environmental toxicants and sharing of clinical experience on practical applications. Chung RT1.
  216. Free Radic Biol Med. 2013 Mar;56:102-11. doi: 10.1016/j.freeradbiomed.2012.11.016. Epub 2012 Nov 30. Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress. Reuland DJ1, Khademi S, Castle CJ, Irwin DC, McCord JM, Miller BF, Hamilton KL.
  217. Planta Med. 2011 Mar;77(4):311-21. doi: 10.1055/s-0030-1250457. Epub 2010 Nov 3. Effects of herbal supplements on drug glucuronidation. Review of clinical, animal, and in vitro studies. Mohamed ME1, Frye RF.
  218. Planta Med. 2006 May;72(6):514-20. Induction of CYP1A by green tea extract in human intestinal cell lines. Netsch MI1, Gutmann H, Schmidlin CB, Aydogan C, Drewe J.
  219. Teratog Carcinog Mutagen. 2003;Suppl 1:313-22. Regulation of hazardous exposure by protective exposure: modulation of phase II detoxification and lipid peroxidation by Camellia sinensis and Swertia chirata. Saha P1, Das S.
  220. Food Chem Toxicol. 2002 Jun;40(6):841-4. Induction of UDP-glucuronosyltransferase 1 (UDP-GT1) gene complex by green tea in male F344 rats. Embola CW1, Sohn OS, Fiala ES, Weisburger JH.
  221. BMC Complement Altern Med. 2014 Dec 9;14:475. doi: 10.1186/1472-6882-14-475. An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects. Evans M1, Paterson E, Barnes DM.
  222. Res Pharm Sci. 2015 Sep-Oct;10(5):429-35. Hydro-alcoholic extract of Raphanus sativus L. var niger attenuates bleomycin-induced pulmonary fibrosis via decreasing transforming growth factor β1 level. Asghari MH1, Hobbenaghi R2, Nazarizadeh A2, Mikaili P3.
  223. Nutr Cancer. 2012;64(7):1038-48. doi: 10.1080/01635581.2012.714831. Spanish black radish (Raphanus sativus L. Var. niger) diet enhances clearance of DMBA and diminishes toxic effects on bone marrow progenitor cells. N'jai AU1, Kemp MQ, Metzger BT, Hanlon PR, Robbins M, Czuyprynski C, Barnes DM.
  224. J Agric Food Chem. 2007 Aug 8;55(16):6439-46. Epub 2007 Jul 6. Aqueous extract from Spanish black radish (Raphanus sativus L. Var. niger) induces detoxification enzymes in the HepG2 human hepatoma cell line. Hanlon PR1, Webber DM, Barnes DM.
  225. Nutr Cancer. 2012 Aug;64(6):856-63. doi: 10.1080/01635581.2012.700994. Epub 2012 Jul 25. The influence of curcumin, quercetin, and eicosapentaenoic acid on the expression of phase II detoxification enzymes in the intestinal cell lines HT-29, Caco-2, HuTu 80, and LT97. Odenthal J1, van Heumen BW, Roelofs HM, te Morsche RH, Marian B, Nagengast FM, Peters WH.
  226. Lab Invest. 2012 Jun;92(6):827-41. doi: 10.1038/labinvest.2012.53. Epub 2012 Mar 26. Curcumin eliminates the inhibitory effect of advanced glycation end-products (AGEs) on gene expression of AGE receptor-1 in hepatic stellate cells in vitro. Lin J1, Tang Y, Kang Q, Chen A.
  227. J Invest Dermatol. 2010 Dec;130(12):2781-9. doi: 10.1038/jid.2010.201. Epub 2010 Jul 22. Transcriptional upregulation of Nrf2-dependent phase II detoxification genes in the involved epidermis of vitiligo vulgaris. Natarajan VT1, Singh A, Kumar AA, Sharma P, Kar HK, Marrot L, Meunier JR, Natarajan K, Rani R, Gokhale RS.
  228. J Appl Toxicol. 2010 Jul;30(5):457-68. doi: 10.1002/jat.1517. Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury. Agarwal R1, Goel SK, Behari JR.
  229. J Ethnopharmacol. 2010 Feb 17;127(3):641-4. doi: 10.1016/j.jep.2009.12.010. Epub 2009 Dec 14. Metabolic intervention of aflatoxin B1 toxicity by curcumin. Nayak S1, Sashidhar RB.
  230. Toxicol Ind Health. 2015 Jun;31(6):523-41. doi: 10.1177/0748233713475524. Epub 2013 Feb 13. Silymarin prevents benzo(a)pyrene-induced toxicity in Wistar rats by modulating xenobiotic-metabolizing enzymes. Kiruthiga PV1, Karthikeyan K2, Archunan G2, Pandian SK1, Devi KP3.
  231. Eur J Pharmacol. 2012 Jan 15;674(2-3):430-8. doi: 10.1016/j.ejphar.2011.11.008. Epub 2011 Nov 12. Colon cancer chemopreventive efficacy of silibinin through perturbation of xenobiotic metabolizing enzymes in experimental rats. Sangeetha N1, Viswanathan P, Balasubramanian T, Nalini N.
  232. Hum Exp Toxicol. 2011 Jan;30(1):38-43. doi: 10.1177/0960327110368418. Epub 2010 Apr 8. Influence of commonly used clinical antidotes on antioxidant systems in human hepatocyte culture intoxicated with alpha-amanitin. Magdalan J1, Piotrowska A, Gomułkiewicz A, Sozański T, Szeląg A, Dziegięl P.
  233. Basic Clin Pharmacol Toxicol. 2007 Jun;100(6):414-9. Silymarin protection against major reactive oxygen species released by environmental toxins: exogenous H2O2 exposure in erythrocytes. Kiruthiga PV1, Shafreen RB, Pandian SK, Devi KP.
  234. Pharmacol Toxicol. 1991 Jul;69(1):9-12. Acetaminophen does not induce oxidative stress in isolated rat hepatocytes: its probable antioxidant effect is potentiated by the flavonoid silybin. Garrido A1, Arancibia C, Campos R, Valenzuela A.
  235. Phytomedicine. 2012 Dec 15;20(1):40-6. doi: 10.1016/j.phymed.2012.09.004. Epub 2012 Oct 13. Absorption and metabolism of milk thistle flavanolignans in humans. Calani L1, Brighenti F, Bruni R, Del Rio D.
  236. Ecotoxicol Environ Saf. 2012 Dec;86:79-85. doi: 10.1016/j.ecoenv.2012.08.031. Epub 2012 Oct 12. Silymarin attenuates benzo(a)pyrene induced toxicity by mitigating ROS production, DNA damage and calcium mediated apoptosis in peripheral blood mononuclear cells (PBMC). Perumal Vijayaraman K1, Muruganantham S, Subramanian M, Shunmugiah KP, Kasi PD.
  237. J Asian Nat Prod Res. 2007 Apr-Aug;9(3-5):245-52. Activation of the SIRT1 pathway and modulation of the cell cycle were involved in silymarin's protection against UV-induced A375-S2 cell apoptosis. Li LH1, Wu LJ, Tashiro SI, Onodera S, Uchiumi F, Ikejima T.
  238. Trends Cell Biol. 2016 Jan 27. pii: S0962-8924(16)00003-9. doi: 10.1016/j.tcb.2015.12.007. [Epub ahead of print] Understanding Ubiquinone. Wang Y1, Hekimi S2.
  239. J Inherit Metab Dis. 2015 Jan;38(1):145-56. doi: 10.1007/s10545-014-9749-9. Epub 2014 Aug 5. Genetic bases and clinical manifestations of coenzyme Q10 (CoQ 10) deficiency. Desbats MA1, Lunardi G, Doimo M, Trevisson E, Salviati L.
  240. J Inherit Metab Dis. 2012 Jul;35(4):679-87. doi: 10.1007/s10545-011-9434-1. Epub 2012 Jan 10. Update on clinical aspects and treatment of selected vitamin-responsive disorders II (riboflavin and CoQ 10). Horvath R1.
  241. Biofactors. 2011 Sep-Oct;37(5):355-60. doi: 10.1002/biof.156. Epub 2011 Jun 14. Non-mitochondrial coenzyme Q. Morré DJ1, Morré DM.
  242. Chem Biol Interact. 2000 Dec 1;129(1-2):77-97. NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Ross D1, Kepa JK, Winski SL, Beall HD, Anwar A, Siegel D.
  243. J Zhejiang Univ Sci B. 2014 Dec;15(12):1039-47. doi: 10.1631/jzus.B1400104. Therapeutic detoxification of quercetin against carbon tetrachloride-induced acute liver injury in mice and its mechanism. Zhang JQ1, Shi L, Xu XN, Huang SC, Lu B, Ji LL, Wang ZT.
  244. J Agric Food Chem. 2014 Jun 25;62(25):5881-6. doi: 10.1021/jf501548g. Epub 2014 Jun 12. Modeling the effect of phase II conjugations on topoisomerase I poisoning: pilot study with luteolin and quercetin. Dellafiora L1, Mena P, Del Rio D, Cozzini P.
  245. J Clin Pharmacol. 2012 Jun;52(6):940-6. doi: 10.1177/0091270011406278. Epub 2011 Jun 16. Effect of quercetin on CYP3A activity in Chinese healthy participants. Duan KM1, Wang SY, Ouyang W, Mao YM, Yang LJ.
  246. Integr Cancer Ther. 2011 Dec;10(4):328-40. doi: 10.1177/1534735410391661. Epub 2010 Dec 31. Exploiting tyrosinase expression and activity in melanocytic tumors: quercetin and the central role of p53. Vargas AJ1, Sittadjody S, Thangasamy T, Mendoza EE, Limesand KH, Burd R.
  247. Clin Exp Pharmacol Physiol. 2009 Aug;36(8):828-33. doi: 10.1111/j.1440-1681.2009.05158.x. Epub 2009 Feb 10. Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers. Chen Y1, Xiao P, Ou-Yang DS, Fan L, Guo D, Wang YN, Han Y, Tu JH, Zhou G, Huang YF, Zhou HH.
  248. J Exp Clin Cancer Res. 2004 Jun;23(2):251-8. Comparative evaluation of cancer chemopreventive efficacy of alpha-tocopherol and quercetin in a murine model. De S1, Chakraborty RN, Ghosh S, Sengupta A, Das S.
  249. Toxicol Lett. 2001 Feb 3;119(1):49-57. Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Valerio LG Jr1, Kepa JK, Pickwell GV, Quattrochi LC.
  250. Adv Exp Med Biol. 2015;851:229-46. doi: 10.1007/978-3-319-16009-2_9. Cytochrome p450 enzymes and electrochemistry: crosstalk with electrodes as redox partners and electron sources. Shumyantseva VV1, Bulko T, Shich E, Makhova A, Kuzikov A, Archakov A.
  251. PLoS One. 2013 Nov 14;8(11):e80994. doi: 10.1371/journal.pone.0080994. eCollection 2013. Role of glucuronidation for hepatic detoxification and urinary elimination of toxic bile acids during biliary obstruction. Perreault M1, Białek A, Trottier J, Verreault M, Caron P, Milkiewicz P, Barbier O.
  252. Drug Metab Dispos. 2012 Dec;40(12):2267-72. doi: 10.1124/dmd.112.047555. Epub 2012 Aug 30. Predictability of metabolism of ibuprofen and naproxen using chimeric mice with human hepatocytes. Sanoh S1, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Uramaru N, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.
  253. J Hepatol. 2012 Jul;57(1):133-40. doi: 10.1016/j.jhep.2012.02.014. Epub 2012 Mar 10. Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health. Dilger K1, Hohenester S, Winkler-Budenhofer U, Bastiaansen BA, Schaap FG, Rust C, Beuers U.
  254. Xenobiotica. 2012 Feb;42(2):195-205. doi: 10.3109/00498254.2011.607196. Epub 2011 Sep 28. The hepatic reductase null mouse as a model for exploring hepatic conjugation of xenobiotics: application to the metabolism of diclofenac. Pickup K1, Gavin A, Jones HB, Karlsson E, Page C, Ratcliffe K, Sarda S, Schulz-Utermoehl T, Wilson I.
  255. Adv Exp Med Biol. 2009;643:353-8. Taurine supplementation and pancreatic remodeling. El Idrissi A1, Boukarrou L, L'Amoreaux W.
  256. Amino Acids. 2004 Dec;27(3-4):327-33. Epub 2004 Apr 26. Effects of taurine in glucose and taurine administration. Kaplan B1, Karabay G, Zağyapan RD, Ozer C, Sayan H, Duyar I.
  257. Altern Med Rev. 1998 Apr;3(2):128-36. Therapeutic applications of taurine. Birdsall TC1.
  258. Mol Med Rep. 2013 May;7(5):1442-52. doi: 10.3892/mmr.2013.1389. Epub 2013 Mar 20. Transcriptomic and proteomic analysis of human hepatic stellate cells treated with natural taurine. Liang J1, Deng X, Wu FS, Tang YF.
  259. J Pharm Sci. 2003 Oct;92(10):2098-108. Inhibition of the rat hepatic microsomal flurbiprofen acyl glucuronidation by bile acids. Mano N1, Goto T, Nikaido A, Narui T, Goto J.
  260. Biochemistry (Mosc). 2015 Mar;80(3):366-73. doi: 10.1134/S0006297915030116. Taurine modulates catalytic activity of cytochrome P450 3A4. Shumyantseva VV1, Makhova AA, Bulko TV, Bernhardt R, Kuzikov AV, Shich EV, Kukes VG, Archakov AI.
  261. J Agric Food Chem. 2011 May 11;59(9):4995-5000. doi: 10.1021/jf1049547. Epub 2011 Mar 22. Taurine is more effective than melatonin on cytochrome P450 2E1 and some oxidative stress markers in streptozotocin-induced diabetic rats. El-Batch M1, Hassan AM, Mahmoud HA.
  262. Clin Chim Acta. 2006 Aug;370(1-2):129-36. Epub 2006 Feb 23. Attenuation of tamoxifen-induced hepatotoxicity by taurine in mice. Tabassum H1, Rehman H, Banerjee BD, Raisuddin S, Parvez S.
  263. Alcohol Alcohol. 1999 Jul-Aug;34(4):529-41. Reversal of ethanol-induced hepatic steatosis and lipid peroxidation by taurine: a study in rats. Kerai MD1, Waterfield CJ, Kenyon SH, Asker DS, Timbrell JA.
  264. Pharm Biol. 2015 Feb;53(2):167-73. doi: 10.3109/13880209.2014.913066. Epub 2014 Sep 22. Protective effect of artichoke leaf extract against paracetamol-induced hepatotoxicity in rats. El Morsy EM1, Kamel R.
  265. Phytomedicine. 2013 Sep 15;20(12):1131-4. doi: 10.1016/j.phymed.2013.06.003. Epub 2013 Jul 3. Protective activity of Cynara scolymus L. leaf extract against chemically induced complex genomic alterations in CHO cells. Jacociunas LV1, de Andrade HH, Lehmann M, Pedersini LW, Ferraz Ade B, da Silva J, Dihl RR.
  266. Pharm Biol. 2013 Sep;51(9):1104-9. doi: 10.3109/13880209.2013.777931. Epub 2013 Jun 7. Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat. Heidarian E1, Rafieian-Kopaei M.
  267. Arzneimittelforschung. 2012 Dec;62(12):650-4. doi: 10.1055/s-0032-1330018. Epub 2012 Nov 29. Effect of zeolite nano-materials and artichoke (Cynara scolymus L.) leaf extract on increase in urinary clearance of systematically absorbed nicotine. Malekshah RE1, Mahjub R, Rastgarpanah M, Ghorbani M, Partoazar AR, Mehr SE, Dehpour AR, Dorkoosh FA.
  268. Free Radic Res. 2000 Nov;33(5):661-5. Activity of artichoke leaf extract on reactive oxygen species in human leukocytes. Pérez-García F1, Adzet T, Cañigueral S.
  269. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003 Dec;147(2):147-53. Metal-chelating properties, electrochemical behavior, scavenging and cytoprotective activities of six natural phenolics. Psotová J1, Lasovský J, Vicar J.
  270. J Ethnopharmacol. 2003 Jun;86(2-3):203-11. Efficacy of different Cynara scolymus preparations on liver complaints. Speroni E1, Cervellati R, Govoni P, Guizzardi S, Renzulli C, Guerra MC.
  271. Phytomedicine. 1994 Sep;1(2):107-15. doi: 10.1016/S0944-7113(11)80027-9. Increase in choleresis by means of artichoke extract. Kirchhoff R1, Beckers C, Kirchhoff GM, Trinczek-Gärtner H, Petrowicz O, Reimann HJ.
  272. Planta Med. 1985 Feb;51(1):50-2. Assay methods for antihepatotoxic activity using peroxide-induced cytotoxicity in primary cultured hepatocytes1. Kiso Y1, Kato O, Hikino H.
  273. Med Chem. 2011 Sep;7(5):480-7. Relevance of drug metabolizing enzyme activity modulation by tea polyphenols in the inhibition of esophageal tumorigenesis. Maliakal P1, Sankpal UT, Basha R, Maliakal C, Ledford A, Wanwimolruk S.
  274. J Pharm Pharmacol. 2001 Oct;53(10):1323-9. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. Maliakal PP1, Wanwimolruk S.
  275. Pak J Pharm Sci. 2014 Jul;27(4):825-9. Effect of leaf extracts of Taraxacum officinale on CCl4 induced hepatotoxicity in rats, in vivo study. Gulfraz M1, Ahamd D1, Ahmad MS1, Qureshi R1, Mahmood RT1, Jabeen N2, Abbasi KS3.
  276. Food Chem Toxicol. 2013 Aug;58:30-6. doi: 10.1016/j.fct.2013.04.023. Epub 2013 Apr 18. Taraxacum official (dandelion) leaf extract alleviates high-fat diet-induced nonalcoholic fatty liver. Davaatseren M1, Hur HJ, Yang HJ, Hwang JT, Park JH, Kim HJ, Kim MJ, Kwon DY, Sung MJ.
  277. J Med Food. 2013 Jan;16(1):26-33. doi: 10.1089/jmf.2012.2226. Epub 2012 Dec 20. Dandelion leaf extract protects against liver injury induced by methionine- and choline-deficient diet in mice. Davaatseren M1, Hur HJ, Yang HJ, Hwang JT, Park JH, Kim HJ, Kim MS, Kim MJ, Kwon DY, Sung MJ.
  278. J Med Food. 2012 Jun;15(6):549-56. doi: 10.1089/jmf.2011.0282. Epub 2012 Mar 16. Antioxidant properties of Taraxacum officinale leaf extract are involved in the protective effect against hepatoxicity induced by acetaminophen in mice. Colle D1, Arantes LP, Gubert P, da Luz SC, Athayde ML, Teixeira Rocha JB, Soares FA.
  279. J Ethnopharmacol. 2010 Aug 9;130(3):569-77. doi: 10.1016/j.jep.2010.05.046. Epub 2010 Jun 2. Antifibrotic activity of Taraxacum officinale root in carbon tetrachloride-induced liver damage in mice. Domitrović R1, Jakovac H, Romić Z, Rahelić D, Tadić Z.
  280. Food Chem Toxicol. 2010 May;48(5):1255-61. doi: 10.1016/j.fct.2010.02.019. Epub 2010 Feb 17. TOP1 and 2, polysaccharides from Taraxacum officinale, attenuate CCl(4)-induced hepatic damage through the modulation of NF-kappaB and its regulatory mediators. Park CM1, Youn HJ, Chang HK, Song YS.
  281. J Ethnopharmacol. 2006 Oct 11;107(3):313-23. Epub 2006 Jul 22. Taraxacum--a review on its phytochemical and pharmacological profile. Schütz K1, Carle R, Schieber A.
  282. Life Sci. 2004 Jan 16;74(9):1149-57. Taraxacum officinale induces cytotoxicity through TNF-alpha and IL-1alpha secretion in Hep G2 cells. Koo HN1, Hong SH, Song BK, Kim CH, Yoo YH, Kim HM.
  283. Cancer Causes Control. 1991 Nov;2(6):427-42. Vegetables, fruit, and cancer. II. Mechanisms. Steinmetz KA1, Potter JD.
  284. Food Chem Toxicol. 2015 Jul;81:160-70. doi: 10.1016/j.fct.2015.04.015. Epub 2015 Apr 17. The antioxidant and antigenotoxic properties of citrus phenolics limonene and naringin. Bacanlı M1, Başaran AA2, Başaran N3.
  285. Springerplus. 2014 Jun 25;3:316. doi: 10.1186/2193-1801-3-316. eCollection 2014. Mitigating role of thymoquinone rich fractions from Nigella sativa oil and its constituents, thymoquinone and limonene on lipidemic-oxidative injury in rats. Ahmad S1, Beg ZH1.
  286. Basic Clin Pharmacol Toxicol. 2013 Mar;112(3):175-81. doi: 10.1111/bcpt.12010. Epub 2012 Oct 25. Protective effects of D-limonene on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rats. Murali R1, Karthikeyan A, Saravanan R.
  287. Acta Pol Pharm. 2015 Jan-Feb;72(1):49-52. The effect of lipoic acid administration on the urinary excretion of thiocyanate in rats exposed to potassium cyanide. Bilska-Wilkosz A, Dudek M, Knutelska J, Włodek L.
  288. J Nutr. 2010 May;140(5):885-92. doi: 10.3945/jn.110.121418. Epub 2010 Mar 17. Sulforaphane and alpha-lipoic acid upregulate the expression of the pi class of glutathione S-transferase through c-jun and Nrf2 activation. Lii CK1, Liu KL, Cheng YP, Lin AH, Chen HW, Tsai CW.
  289. Mol Cell Biochem. 2008 Feb;309(1-2):109-16. Epub 2007 Nov 16. Effect of vitamin C and lipoic acid on streptozotocin-induced diabetes gene expression: mRNA and protein expressions of Cu-Zn SOD and catalase. Sadi G1, Yilmaz O, Güray T.
  290. Arch Environ Health. 2003 Aug;58(8):528-32. Lipoic acid as a potential first agent for protection from mycotoxins and treatment of mycotoxicosis. Rogers SA1.
  291. Free Radic Res. 2002 Jun;36(6):695-9. The neuroprotective antioxidant alpha-lipoic acid induces detoxication enzymes in cultured astroglial cells. Flier J1, Van Muiswinkel FL, Jongenelen CA, Drukarch B.
  292. J Nutr Sci Vitaminol (Tokyo). 2009 Apr;55(2):126-30. Protective effect of lipoic acid against acrolein-induced cytotoxicity in IMR-90 human fibroblasts. Jia L1, Zhang Z, Zhai L, Bai Y.
  293. J Neurochem. 2006 Aug;98(4):1242-51. Epub 2006 Jun 19. RS-alpha-lipoic acid protects cholinergic cells against sodium nitroprusside and amyloid-beta neurotoxicity through restoration of acetyl-CoA level. Bielarczyk H1, Gul S, Ronowska A, Bizon-Zygmanska D, Pawelczyk T, Szutowicz A.
  294. Environ Toxicol Pharmacol. 2005 Jul;20(1):246-9. doi: 10.1016/j.etap.2004.10.006. Epub 2004 Dec 15. Substantial inhibition of chromate induced DNA-protein crosslink formation in vivo by α-lipoic acid. Budhwar R1, Kumar S.
  295. Clin Dermatol. 2009 Mar-Apr;27(2):217-24. doi: 10.1016/j.clindermatol.2008.01.012. Ascorbigen: chemistry, occurrence, and biologic properties. Wagner AE1, Rimbach G.
  296. Bull Exp Biol Med. 2001 Jun;131(6):544-7. Effect of nutritional indoles on activity of xenobiotic metabolism enzymes and T-2 toxicity in rats. Kravchenko LV1, Avren'eva LI, Guseva GV, Posdnyakov AL, Tutel'yan VA.
  297. Food Chem Toxicol. 2012 Aug;50(8):2822-30. doi: 10.1016/j.fct.2012.05.044. Epub 2012 Jun 1. Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes. La Marca M1, Beffy P, Della Croce C, Gervasi PG, Iori R, Puccinelli E, Longo V.
  298. Food Chem. 2014 Aug 15;157:105-10. doi: 10.1016/j.foodchem.2014.01.082. Epub 2014 Feb 5. Isothiocyanates may chemically detoxify mutagenic amines formed in heat processed meat. Lewandowska A1, Przychodzeń W2, Kusznierewicz B3, Kołodziejski D3, Namieśnik J4, Bartoszek A5.
  299. Nutr Rev. 2012 Nov;70(11):654-65. doi: 10.1111/j.1753-4887.2012.00532.x. Epub 2012 Oct 12. Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli. James D1, Devaraj S, Bellur P, Lakkanna S, Vicini J, Boddupalli S.
  300. Front Genet. 2012 Jan 24;3:7. doi: 10.3389/fgene.2012.00007. eCollection 2012. Induction of phase 2 antioxidant enzymes by broccoli sulforaphane: perspectives in maintaining the antioxidant activity of vitamins a, C, and e. Boddupalli S1, Mein JR, Lakkanna S, James DR.
  301. J Agric Food Chem. 2009 Aug 26;57(16):7304-10. doi: 10.1021/jf901926b. Feeding tomato and broccoli powders enriched with bioactives improves bioactivity markers in rats. Liu AG1, Volker SE, Jeffery EH, Erdman JW Jr.
  302. Cancer Res. 2004 Aug 15;64(16):5767-74. A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Myzak MC1, Karplus PA, Chung FL, Dashwood RH.
  303. Front Microbiol. 2013 Dec 24;4:396. doi: 10.3389/fmicb.2013.00396. Bile resistance mechanisms in Lactobacillus and Bifidobacterium. Ruiz L1, Margolles A1, Sánchez B1.
  304. Yakugaku Zasshi. 2012;132(3):301-10. Effects of intestinal flora on the expression of cytochrome P450 3A in the liver. [Article in Japanese] Ishii M1, Toda T, Ikarashi N, Ochiai W, Sugiyama K.
  305. Int J Artif Organs. 1983 Jul;6(4):207-13. In vivo evaluation of a composite sorbent for the treatment of paraquat intoxication by hemoperfusion. Lotan N, Siderman S, Tabak A, Taitelman U, Mihich H, Lupovich S.
  306. Sci Total Environ. 2015 Jun 1;517:86-95. doi: 10.1016/j.scitotenv.2015.02.036. Epub 2015 Feb 24. Interaction of human adenoviruses and coliphages with kaolinite and bentonite. Bellou MI1, Syngouna VI2, Tselepi MA1, Kokkinos PA1, Paparrodopoulos SC1, Vantarakis A3, Chrysikopoulos CV4
  307. lloids Surf B Biointerfaces. 2011 Mar;83(1):122-7. doi: 10.1016/j.colsurfb.2010.11.018. Epub 2010 Nov 17. Preferential adsorption of extracellular polymeric substances from bacteria on clay minerals and iron oxide. Cao Y1, Wei X, Cai P, Huang Q, Rong X, Liang W.
  308. J Hazard Mater. 2010 Jul 15;179(1-3):684-91. doi: 10.1016/j.jhazmat.2010.03.056. Epub 2010 Mar 19. Sorption of triclosan onto activated carbon, kaolinite and montmorillonite: effects of pH, ionic strength, and humic acid. Behera SK1, Oh SY, Park HS.
  309. J Hazard Mater. 2009 Aug 30;168(1):210-4. doi: 10.1016/j.jhazmat.2009.02.021. Epub 2009 Feb 13. Sorption of endrin to montmorillonite and kaolinite clays. Peng X1, Wang J, Fan B, Luan Z.
  310. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2007 Mar;42(4):463-9. Arsenic(V) adsorption mechanism using kaolinite, montmorillonite and illite from aqueous medium. Mohapatra D1, Mishra D, Chaudhury GR, Das RP.
  311. J Environ Sci Health B. 2006;41(6):765-79. Sorption and desorption behavior of chloroanilines and chlorophenols on montmorillonite and kaolinite. Polati S1, Gosetti F, Gianotti V, Gennaro MC.
  312. Environ Toxicol Chem. 2002 Jul;21(7):1390-7. Adsorption behavior of toxic tributyltin to clay-rich sediments under various environmental conditions. Hoch M1, Alonso-Azcarate J, Lischick M.
  313. Eur J Clin Pharmacol. 1975 Jun 13;8(5):293-9. Mechanism of the inhibitory effect of PAS granules on the absorption of rifampicin: adsorption of rifampicin by an excipient, bentonite. Boman G, Lundgren P, Stjernström G.
  314. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012;29(5):809-18. doi: 10.1080/19440049.2011.651628. Epub 2012 Feb 10. Calcium montmorillonite clay reduces urinary biomarkers of fumonisin B₁ exposure in rats and humans. Robinson A1, Johnson NM, Strey A, Taylor JF, Marroquin-Cardona A, Mitchell NJ, Afriyie-Gyawu E, Ankrah NA, Williams JH, Wang JS, Jolly PE, Nachman RJ, Phillips TD.
  315. Elements (Que). 2009 Apr 1;5(2):99-104. Bentonite, Bandaids, and Borborygmi. Williams LB1, Haydel SE, Ferrell RE.
  316. J Med Food. 2015 Feb;18(2):182-9. doi: 10.1089/jmf.2014.3159. Epub 2015 Jan 20. Chlorella ethanol extract induced phase II enzyme through NFE2L2 (nuclear factor [erythroid-derived] 2-like 2, NRF2) activation and protected ethanol-induced hepatoxicity. Byun HG1, Lee JK.
  317. Environ Toxicol Pharmacol. 2015 Nov;40(3):758-63. doi: 10.1016/j.etap.2015.09.005. Epub 2015 Sep 12. Epigenetic modulation of Chlorella (Chlorella vulgaris) on exposure to polycyclic aromatic hydrocarbons. Yang M1, Youn JI2, Kim SJ3, Park JY4.
  318. Environ Toxicol Pharmacol. 2015 Jan;39(1):441-6. doi: 10.1016/j.etap.2014.11.015. Epub 2014 Dec 3. Detoxification of chlorella supplement on heterocyclic amines in Korean young adults. Lee I1, Tran M2, Evans-Nguyen T2, Stickle D3, Kim S1, Han J4, Park JY5, Yang M6.
  319. Mol Biosyst. 2014 Jan;10(1):149-60. doi: 10.1039/c3mb70425d. NMR-based metabolomics and LC-MS/MS quantification reveal metal-specific tolerance and redox homeostasis in Chlorella vulgaris. Zhang W1, Tan NG, Li SF.
  320. Drug Chem Toxicol. 1984;7(1):57-71. Detoxification of chlordecone poisoned rats with chlorella and chlorella derived sporopollenin. Pore RS.
  321. J Environ Sci Eng. 2014 Apr;56(2):229-32. Biosorption of Lead from Wastewater Using Fresh Water Algae Chlorella. Kanchana S, Jeyanthi J.
  322. Environ Pollut. 2016 Feb 4;212:290-298. doi: 10.1016/j.envpol.2016.01.063. [Epub ahead of print] Adsorption-uptake-metabolism kinetic model on the removal of BDE-47 by a Chlorella isolate. Deng D1, Tam NF2.
  323. J Hazard Mater. 2015 Dec 15;299:67-77. doi: 10.1016/j.jhazmat.2015.06.011. Epub 2015 Jun 9. The adsorption potential and recovery of thallium using green micro-algae from eutrophic water sources. Birungi ZS1, Chirwa EM2.
  324. Environ Sci Pollut Res Int. 2015 Jul;22(14):10811-23. doi: 10.1007/s11356-015-4277-1. Epub 2015 Mar 14. Bioremoval of the azo dye Congo Red by the microalga Chlorella vulgaris. Hernández-Zamora M1, Cristiani-Urbina E, Martínez-Jerónimo F, Perales-Vela HV, Ponce-Noyola T, Montes-Horcasitas Mdel C, Cañizares-Villanueva RO.
  325. Bioresour Technol. 2011 Nov;102(22):10230-8. doi: 10.1016/j.biortech.2011.08.070. Epub 2011 Sep 1. Removal and biodegradation of nonylphenol by immobilized Chlorella vulgaris. Gao QT1, Wong YS, Tam NF.
  326. Bioresour Technol. 2010 Oct;101(19):7314-22. doi: 10.1016/j.biortech.2010.04.092. Epub 2010 May 23. Use of Chlorella vulgaris for bioremediation of textile wastewater. Lim SL1, Chu WL, Phang SM.
  327. J Hazard Mater. 2010 Mar 15;175(1-3):844-9. doi: 10.1016/j.jhazmat.2009.10.087. Epub 2009 Oct 30. Removal of malachite green from aqueous solution using low-cost chlorella-based biomass. Tsai WT1, Chen HR.
  328. Bioresour Technol. 2008 Jun;99(9):3600-8. Epub 2007 Sep 27. Kinetic and equilibrium modeling of chromium (VI) biosorption on fresh and spent Spirulina platensis/Chlorella vulgaris biomass. Gokhale SV1, Jyoti KK, Lele SS.
  329. Water Sci Technol. 2002;46(11-12):195-201. Removal of pyrene by different microalgal species. Lei AP1, Wong YS, Tam NF.
  330. Environ Pollut. 2001;114(1):85-92. Repeated use of two Chlorella species, C. vulgaris and WW1 for cyclic nickel biosorption. Tam NF1, Wong JP, Wong YS.
  331. Mol Nutr Food Res. 2012 May;56(5):797-809. doi: 10.1002/mnfr.201100697. Capsaicin induces CYP3A4 expression via pregnane X receptor and CCAAT/enhancer-binding protein β activation. Han EH1, Kim HG, Choi JH, Jang YJ, Lee SS, Kwon KI, Kim E, Noh K, Jeong TC, Hwang YP, Chung YC, Kang W, Jeong HG.
  332. Mol Cell Biochem. 2009 Nov;331(1-2):135-43. doi: 10.1007/s11010-009-0151-0. Epub 2009 May 18. Capsaicin alleviates the imbalance in xenobiotic metabolizing enzymes and tumor markers during experimental lung tumorigenesis. Anandakumar P1, Kamaraj S, Jagan S, Ramakrishnan G, Naveenkumar C, Asokkumar S, Devaki T.
  333. Int J Biol Sci. 2014 Feb 21;10(3):285-95. doi: 10.7150/ijbs.7730. eCollection 2014. Capsaicin mediates cell cycle arrest and apoptosis in human colon cancer cells via stabilizing and activating p53. Jin J1, Lin G1, Huang H1, Xu D1, Yu H1, Ma X1, Zhu L1, Ma D1, Jiang H1.
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  1. Cancer Lett. 1997 Mar 19;114(1-2):221-3. Modulation of aflatoxin B1 carcinogenicity, genotoxicity and metabolism in rat liver by dietary carotenoids: evidence for a protective effect of CYP1A inducers. Gradelet S1, Astorg P, Le Bon AM, Bergès R, Suschetet M.
  2. Vopr Pitan. 1987 Jul-Aug;(4):61-3. Effect of vitamin A deficiency on surfactants and enzymes of xenobiotic metabolism in the rat lung. [Article in Russian] Iakovleva OA, Pentiuk AA, Gutsol VI, Bogdanov NG.
  3. Vopr Med Khim. 1986 Mar-Apr;32(2):130-4. Activity of enzymes of xenobiotic metabolism in the liver of rats with vitamin A deficiency and mycotoxicosis T-2. [Article in Russian] Kranauskas AE, Kravchenko LV, Kon' IIa, Tutel'ian VA.
  4. Int J Vitam Nutr Res. 1976;46(1):14-23. Hepatic drug metabolism and lipid peroxidation in thiamine deficient rats. Galdhar NR, Pawar SS.
  5. Vopr Med Khim. 1988 May-Jun;34(3):45-8. Metabolism and toxicity of various xenobiotics in vitamin B1 deficiency and after administration of thiamine and thiamine diphosphate. [Article in Russian] Lychko AP, Pentiuk AA, Lutsiuk NB.
  6. Arch Biochem Biophys. 2008 Jul 15;475(2):93-9. doi: 10.1016/j.abb.2008.04.014. Epub 2008 Apr 20. Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase. Kranendonk M1, Marohnic CC, Panda SP, Duarte MP, Oliveira JS, Masters BS, Rueff J.
  7. Biochim Biophys Acta. 2014 Jul;1840(7):2289-98. doi: 10.1016/j.bbagen.2014.03.019. Epub 2014 Apr 3. Ascorbic acid deficiency affects genes for oxidation-reduction and lipid metabolism in livers from SMP30/GNL knockout mice. Takahashi K1, Kishimoto Y1, Konishi T2, Fujita Y3, Ito M3, Shimokado K4, Maruyama N5, Ishigami A6.
  8. Arch Biochem Biophys. 2004 Mar 1;423(1):6-11. Vitamin E, nuclear receptors and xenobiotic metabolism. Traber MG1.
  9. Drug Metab Dispos. 2015 Jan;43(1):126-39. doi: 10.1124/dmd.114.060350. Epub 2014 Oct 22. Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation. Manevski N1, Swart P1, Balavenkatraman KK1, Bertschi B1, Camenisch G1, Kretz O1, Schiller H1, Walles M1, Ling B1, Wettstein R1, Schaefer DJ1, Itin P1, Ashton-Chess J1, Pognan F1, Wolf A1, Litherland K2.
  10. Toxicon. 2007 Sep 1;50(3):339-48. Epub 2007 Apr 22. The effect of feeding piglets with the diet containing green tea extracts or coumarin on in vitro metabolism of aflatoxin B1 by their tissues. Tulayakul P1, Dong KS, Li JY, Manabe N, Kumagai S.
  11. Environ Toxicol Pharmacol. 2009 Jan;27(1):120-6. doi: 10.1016/j.etap.2008.09.004. Epub 2008 Sep 23. Taurine enhances the metabolism and detoxification of ethanol and prevents hepatic fibrosis in rats treated with iron and alcohol. Devi SL1, Viswanathan P, Anuradha CV.
  12. Life Sci. 1995;56(22):1845-55. Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential.Surh YJ1, Lee SS.
  13. J Am Diet Assoc. 2003 Aug;103(8):1029-38. Nutritional cofactor treatment in mitochondrial disorders. Marriage B1, Clandinin MT, Glerum DM.
  14. Free Radic Biol Med. 1992;12(5):397-407. Role of physiological antioxidants in chromium(VI)-induced cellular injury. Sugiyama M1.
  15. J Int Med Res. 2011;39(6):2330-4. Long-term, high intake of vitamin C decreases size and increases quantity of liver mitochondria in Guinea-pigs. Feuring M1, Schultz A, Hersemeyer K.
  16. J Biol Chem. 2003 Sep 26;278(39):37948-56. Epub 2003 Jul 3. NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons. Lee JM1, Shih AY, Murphy TH, Johnson JA.
  17. Nutr Res. 2014 Nov;34(11):907-29. doi: 10.1016/j.nutres.2014.07.010. Epub 2014 Jul 18. Carotenoids, inflammation, and oxidative stress--implications of cellular signaling pathways and relation to chronic disease prevention. Kaulmann A1, Bohn T2.
  18. FASEB J. 2013 Feb;27(2):612-21. doi: 10.1096/fj.12-209361. Epub 2012 Nov 12. Tissue-specific oxidative stress and loss of mitochondria in CoQ-deficient Pdss2 mutant mice. Quinzii CM1, Garone C, Emmanuele V, Tadesse S, Krishna S, Dorado B, Hirano M.
  19. Xenobiotica. 2016 Jan;46(1):25-33. doi: 10.3109/00498254.2015.1049576. Epub 2015 Jul 30. Interplay of metabolizing enzymes and transporter of xenobiotics. Lim HY1, Ho QS1, Wong KP1.
  20. Arch Pharm Res. 2005 Mar;28(3):249-68. Induction of phase I, II and III drug metabolism/transport by xenobiotics. Xu C1, Li CY, Kong AN.
  21. J Hazard Mater. 2009 Aug 30;168(1):319-25. doi: 10.1016/j.jhazmat.2009.02.026. Epub 2009 Feb 20. Removal of lead and zinc ions from water by low cost adsorbents. Mishra PC1, Patel RK.
  22. Arch Pharm Res. 2013 Sep;36(9):1140-8. doi: 10.1007/s12272-013-0110-x. Epub 2013 Apr 17. Hepatoprotective effect of methylsulfonylmethane against carbon tetrachloride-induced acute liver injury in rats. Kamel R1, El Morsy EM.
  23. World J Gastroenterol. 2014 Oct 28;20(40):14787-804. doi: 10.3748/wjg.v20.i40.14787. Review of natural products with hepatoprotective effects. Madrigal-Santillán E1, Madrigal-Bujaidar E1, Álvarez-González I1, Sumaya-Martínez MT1, Gutiérrez-Salinas J1, Bautista M1, Morales-González Á1, García-Luna y González-Rubio M1, Aguilar-Faisal JL1, Morales-González JA1.
  24. Toxicol In Vitro. 1997 Oct;11(5):669-72. Antioxidant and hepatoprotective effects of artichoke extracts and constituents in cultured rat hepatocytes. Gebhardt R1, Fausel M.
  25. J Nat Prod. 1987 Jul-Aug;50(4):612-7. Hepatoprotective activity of polyphenolic compounds from Cynara scolymus against CCl4 toxicity in isolated rat hepatocytes. Adzet T1, Camarasa J, Laguna JC.
  26. Exp Biol Med (Maywood). 2014 Apr;239(4):465-76. doi: 10.1177/1535370213520112. Epub 2014 Feb 28. D-limonene suppresses doxorubicin-induced oxidative stress and inflammation via repression of COX-2, iNOS, and NFκB in kidneys of Wistar rats. Rehman MU1, Tahir M, Khan AQ, Khan R, Oday-O-Hamiza, Lateef A, Hassan SK, Rashid S, Ali N, Zeeshan M, Sultana S.
  27. Oxid Med Cell Longev. 2015;2015:619560. doi: 10.1155/2015/619560. Epub 2015 Oct 20. Dandelion Extracts Protect Human Skin Fibroblasts from UVB Damage and Cellular Senescence. Yang Y1, Li S2.
  28. Pharmacol Res. 2013 Dec;78:28-40. doi: 10.1016/j.phrs.2013.09.009. Epub 2013 Oct 10. Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes. Kleszczyński K1, Ernst IM, Wagner AE, Kruse N, Zillikens D, Rimbach G, Fischer TW.
  29. Anticancer Res. 1999 May-Jun;19(3A):1887-91. Inhibitory potential of Chlorella vulgaris (E-25) on mouse skin papillomagenesis and xenobiotic detoxication system. Singh A1, Singh SP, Bamezai R.
  30. Cancer Detect Prev. 2005;29(5):470-8. Epub 2005 Sep 26. Amelioration of immune cell number depletion and potentiation of depressed detoxification system of tumor-bearing mice by curcumin. Pal S1, Bhattacharyya S, Choudhuri T, Datta GK, Das T, Sa G.
  31. Biochem Soc Trans. 2003 Dec;31(Pt 6):1390-3. Toxicity of glyoxals--role of oxidative stress, metabolic detoxification and thiamine deficiency. Shangari N1, Bruce WR, Poon R, O'Brien PJ.
  32. FEBS Lett. 2005 Oct 24;579(25):5596-602. Epub 2005 Sep 28. The effects of partial thiamin deficiency and oxidative stress (i.e., glyoxal and methylglyoxal) on the levels of alpha-oxoaldehyde plasma protein adducts in Fischer 344 rats. Shangari N1, Depeint F, Furrer R, Bruce WR, O'Brien PJ.
  33. Biol Trace Elem Res. 2015 Nov;168(1):122-32. doi: 10.1007/s12011-015-0324-5. Epub 2015 Apr 9. Arsenic-Induced Antioxidant Depletion, Oxidative DNA Breakage, and Tissue Damages are Prevented by the Combined Action of Folate and Vitamin B12. Acharyya N1,2,3, Deb B3, Chattopadhyay S3, Maiti S4,5,6.
  34. PLoS One. 2015 Aug 13;10(8):e0131097. doi: 10.1371/journal.pone.0131097. eCollection 2015. Vitamin C Compound Mixtures Prevent Ozone-Induced Oxidative Damage in Human Keratinocytes as Initial Assessment of Pollution Protection. Valacchi G1, Sticozzi C2, Belmonte G2, Cervellati F2, Demaude J3, Chen N4, Krol Y5, Oresajo C4.
  35. Free Radic Biol Med. 2013 Aug;61:151-60. doi: 10.1016/j.freeradbiomed.2013.03.021. Epub 2013 Mar 31. Antioxidant compound supplementation prevents oxidative damage in a Drosophila model of Parkinson's disease. Casani S1, Gómez-Pastor R2, Matallana E3, Paricio N4.
  36. Br J Nutr. 2012 Jun;107(11):1645-54. doi: 10.1017/S0007114511004806. Epub 2011 Sep 16. Effect of ascorbic acid-rich diet on in vivo-induced oxidative stress. Alleva R1, Di Donato F, Strafella E, Staffolani S, Nocchi L, Borghi B, Pignotti E, Santarelli L, Tomasetti M.
  37. Cell Death Dis. 2013 Mar 21;4:e554. doi: 10.1038/cddis.2013.78. Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway. Jin M1, Ande A, Kumar A, Kumar S.
  38. Toxicol Lett. 2006 Sep 30;166(1):27-36. Epub 2006 May 16. Tissue-specific effect of ascorbic acid supplementation on the expression of cytochrome P450 2E1 and oxidative stress in streptozotocin-induced diabetic rats. Ahn T1, Yun CH, Oh DB.
  39. Indian J Biochem Biophys. 2003 Oct;40(5):309-14. Cytochrome P450-mediated oxidative damage of nuclear membrane proteins and its prevention by vitamin C. Ghosh MK1, Arun R, Chattopadhyay DJ, Chatterjee IB.
  40. Cell Biol Toxicol. 2011 Dec;27(6):439-53. doi: 10.1007/s10565-011-9198-2. Epub 2011 Aug 18. Increased oxidative stress and cytotoxicity by hydrogen sulfide in HepG2 cells overexpressing cytochrome P450 2E1. Caro AA1, Thompson S, Tackett J
  41. Toxicol Appl Pharmacol. 2001 Mar 1;171(2):85-93. Polychlorinated biphenyl-induced effects on metabolic enzymes, AP-1 binding, vitamin E, and oxidative stress in the rat liver. Twaroski TP1, O'Brien ML, Larmonier N, Glauert HP, Robertson LW.
  42. Am J Pathol. 2005 Jun;166(6):1681-90. Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress. Zhou Z1, Wang L, Song Z, Saari JT, McClain CJ, Kang YJ.
  43. Biol Pharm Bull. 2013;36(7):1095-110. Sulphur antioxidants inhibit oxidative stress induced retinal ganglion cell death by scavenging reactive oxygen species but influence nuclear factor (erythroid-derived 2)-like 2 signalling pathway differently. Majid AS1, Yin ZQ, Ji D.
  44. J Physiol Biochem. 2010 Jun;66(2):143-51. doi: 10.1007/s13105-010-0019-5. Epub 2010 Jun 1. Protective effect of green tea on lead-induced oxidative damage in rat's blood and brain tissue homogenates. Hamed EA1, Meki AR, Abd El-Mottaleb NA.
  45. Mol Carcinog. 2007 Sep;46(9):797-806. Chemoprevention of rat mammary carcinogenesis by black tea polyphenols: modulation of xenobiotic-metabolizing enzymes, oxidative stress, cell proliferation, apoptosis, and angiogenesis. Kumaraguruparan R1, Seshagiri PB, Hara Y, Nagini S.
  46. Food Chem Toxicol. 2013 Sep;59:739-47. doi: 10.1016/j.fct.2013.07.032. Epub 2013 Jul 18. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Gao S1, Duan X, Wang X, Dong D, Liu D, Li X, Sun G, Li B.
  47. J Vet Med Sci. 2012 May;74(5):583-9. Epub 2011 Dec 19. Effects of oxidative stress caused by tert-butylhydroquinone on cytotoxicity in MDCK cells. Shibuya N1, Kobayashi S, Yoshikawa Y, Watanabe K, Orino K.
  48. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):395-403. Curcumin activates defensive genes and protects neurons against oxidative stress. Scapagnini G1, Colombrita C, Amadio M, D'Agata V, Arcelli E, Sapienza M, Quattrone A, Calabrese V.
  49. FASEB J. 2010 Oct;24(10):3733-43. doi: 10.1096/fj.09-152728. Epub 2010 May 21. Reactive oxygen species, oxidative stress, and cell death correlate with level of CoQ10 deficiency. Quinzii CM1, López LC, Gilkerson RW, Dorado B, Coku J, Naini AB, Lagier-Tourenne C, Schuelke M, Salviati L, Carrozzo R, Santorelli F, Rahman S, Tazir M, Koenig M, DiMauro S, Hirano M.
  50. Exp Neurol. 2001 Nov;172(1):211-9. Taurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy. Obrosova IG1, Fathallah L, Stevens MJ.
  51. Free Radic Res. 2010 Mar;44(3):340-55. doi: 10.3109/10715760903513017. Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. Das J1, Ghosh J, Manna P, Sil PC.
  52. Amino Acids. 2009 Mar;36(3):417-28. doi: 10.1007/s00726-008-0094-x. Epub 2008 Apr 15. Taurine plays a beneficial role against cadmium-induced oxidative renal dysfunction. Manna P1, Sinha M, Sil PC.
  53. Mol Nutr Food Res. 2014 Jan;58(1):211-5. doi: 10.1002/mnfr.201300282. Epub 2013 Nov 20. Investigation of the in vivo antioxidative activity of Cynara scolymus (artichoke) leaf extract in the streptozotocin-induced diabetic rat. Magielse J1, Verlaet A, Breynaert A, Keenoy BM, Apers S, Pieters L, Hermans N.
  54. Toxicol Appl Pharmacol. 1997 Jun;144(2):279-86. Antioxidative and protective properties of extracts from leaves of the artichoke (Cynara scolymus L.) against hydroperoxide-induced oxidative stress in cultured rat hepatocytes. Gebhardt R1.
  55. Lik Sprava. 2014 Jan-Feb;(1-2):140-5. Oxidative stress and antioxidant therapy with alpha-lipoic acid inclusion in acute poisoning by herbicide based on 2,4-dichlorphenoxyacetic acid. [Article in Ukrainian] Kharchenko OA, Balan HM, Bubalo NN, Mymrenko TV.
  56. Postepy Hig Med Dosw (Online). 2015 Mar 4;69:270-6. doi: 10.5604/17322693.1142473. Anti-oxidative and anti-inflammatory effects of lipoic acid in rat liver. Goraca A1, Huk-Kolega H1, Kowalczyk A1, Skibska B2.
  57. Food Chem Toxicol. 2013 Sep;59:339-55. doi: 10.1016/j.fct.2013.06.019. Epub 2013 Jun 20. Role of α-lipoic acid in dextran sulfate sodium-induced ulcerative colitis in mice: studies on inflammation, oxidative stress, DNA damage and fibrosis. Trivedi PP1, Jena GB.
  58. Altern Med Rev. 2006 Jun;11(2):114-27. Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity. Patrick L.
  59. Plant Foods Hum Nutr. 2010 Sep;65(3):193-9. doi: 10.1007/s11130-010-0182-4. Dietary broccoli sprouts protect against myocardial oxidative damage and cell death during ischemia-reperfusion. Akhlaghi M1, Bandy B.
  60. Free Radic Biol Med. 2010 Dec 1; 49(11): 1603–1616. Published online 2010 Sep 16. doi:  10.1016/j.freeradbiomed.2010.09.006 Oxidative stress, inflammation, and cancer: How are they linked? Simone Reuter, Subash C. Gupta, Madan M. Chaturvedi, and Bharat B. Aggarwal
  61. Nutr Cancer. 2002;43(1):103-10. Mutagenicity of food-derived carcinogens and the effect of antioxidant vitamins. Montgomery BA1, Murphy J, Chen JJ, Desai VG, McGarrity L, Morris SM, Casciano DA, Aidoo A.
  62. J Cancer Res Clin Oncol. 2011 Apr;137(4):677-86. doi: 10.1007/s00432-010-0926-4. Epub 2010 Jun 16. Chemopreventive effects of zinc on prostate carcinogenesis induced by N-methyl-N-nitrosourea and testosterone in adult male Sprague-Dawley rats. Banudevi S1, Elumalai P, Arunkumar R, Senthilkumar K, Gunadharini DN, Sharmila G, Arunakaran J.
  63. Toxicol In Vitro. 2006 Mar;20(2):187-210. Epub 2005 Nov 11. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Moon YJ1, Wang X, Morris ME.
  64. Carcinogenesis. 2008 May;29(5):1022-32. doi: 10.1093/carcin/bgn064. Epub 2008 Mar 4. Dietary curcumin modulates transcriptional regulators of phase I and phase II enzymes in benzo[a]pyrene-treated mice: mechanism of its anti-initiating action. Garg R1, Gupta S, Maru GB.
  65. Pharmacol Toxicol. 2003 Jan;92(1):33-8. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Iqbal M1, Sharma SD, Okazaki Y, Fujisawa M, Okada S.
  66. Int J Biochem Cell Biol. 1998 Apr;30(4):445-56. Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver. Piper JT1, Singhal SS, Salameh MS, Torman RT, Awasthi YC, Awasthi S.
  67. Mol Cell Biochem. 2013 May;377(1-2):163-76. doi: 10.1007/s11010-013-1582-1. Epub 2013 Feb 9. Dietary supplementation of silymarin is associated with decreased cell proliferation, increased apoptosis, and activation of detoxification system in hepatocellular carcinoma. Gopalakrishnan R1, Sundaram J, Sattu K, Pandi A, Thiruvengadam D.
  68. Int J Cancer. 2002 Oct 10;101(5):461-8. Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats. Kohno H1, Tanaka T, Kawabata K, Hirose Y, Sugie S, Tsuda H, Mori H.
  69. Carcinogenesis. 1999 Nov;20(11):2101-8. Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemoprevention. Zhao J1, Agarwal R.
  70. Carcinogenesis. 2003 Oct;24(10):1651-6. Epub 2003 Jul 17. Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens. van der Logt EM1, Roelofs HM, Nagengast FM, Peters WH.
  71. Free Radic Res. 2012 Jan;46(1):41-9. doi: 10.3109/10715762.2011.637204. Epub 2011 Nov 22. Quercetin suppresses cytochrome P450 mediated ROS generation and NFκB activation to inhibit the development of 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinomas. Priyadarsini RV1, Nagini S.
  72. Carcinogenesis. 1993 Jun;14(6):1221-3. Effects of anticarcinogenic monoterpenes on phase II hepatic metabolizing enzymes. Elegbede JA1, Maltzman TH, Elson CE, Gould MN.
  73. Carcinogenesis. 2003 Dec;24(12):1903-11. Epub 2003 Aug 29. Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes. Bacon JR1, Williamson G, Garner RC, Lappin G, Langouët S, Bao Y.
  74. Drug Chem Toxicol. 2015 Oct;38(4):442-51. doi: 10.3109/01480545.2014.992072. Epub 2015 Jan 22. Protective effects of silymarin on epirubicin-induced mucosal barrier injury of the gastrointestinal tract. Sasu A1, Herman H2, Mariasiu T3, Rosu M2, Balta C2, Anghel N3, Miutescu E4, Cotoraci C1, Hermenean A2,3.
  75. Biochim Biophys Acta. 1998 Mar 2;1379(3):325-36. Effects of the sulforaphane analog compound 30, indole-3-carbinol, D-limonene or relafen on glutathione S-transferases and glutathione peroxidase of the rat digestive tract. van Lieshout EM1, Posner GH, Woodard BT, Peters WH.
  76. Digestion. 1993;54(1):24-31. Role of nitric oxide and prostaglandins in gastroprotection induced by capsaicin and papaverine. Brzozowski T1, Drozdowicz D, Szlachcic A, Pytko-Polonczyk J, Majka J, Konturek SJ.
  77. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(10):1678-87. doi: 10.1080/19440049.2014.943304. Epub 2014 Aug 30. Probiotic lactic acid bacteria detoxify N-nitrosodimethylamine. Nowak A1, Kuberski S, Libudzisz Z.
  78. Curr Opin Biotechnol. 2010 Apr;21(2):157-67. doi: 10.1016/j.copbio.2010.03.016. Epub 2010 Apr 21. Interaction of probiotics and pathogens--benefits to human health? Salminen S1, Nybom S, Meriluoto J, Collado MC, Vesterlund S, El-Nezami H.
  79. Can J Microbiol. 2006 Sep;52(9):877-85. Probiotic bacteria as potential detoxification tools: assessing their heavy metal binding isotherms. Ibrahim F1, Halttunen T, Tahvonen R, Salminen S.
  80. Med Hypotheses. 2002 May;58(5):382-5. Probiotics as an adjuvant to detoxification protocols. Brudnak MA1.
  81. Am J Clin Nutr. 2001 Feb;73(2 Suppl):451S-455S. Protective role of probiotics and prebiotics in colon cancer. Wollowski I1, Rechkemmer G, Pool-Zobel BL.
  82. FASEB J. 2008 Feb;22(2):538-47. Epub 2007 Sep 20. Inflammation resolved by retinoid X receptor-mediated inactivation of leukotriene signaling pathways. Kalsotra A1, Du L, Wang Y, Ladd PA, Kikuta Y, Duvic M, Boyd AS, Keeney DS, Strobel HW.
  83. Inflammation. 2013 Oct;36(5):1111-21. doi: 10.1007/s10753-013-9645-8. Effect of methylsulfonylmethane on paraquat-induced acute lung and liver injury in mice. Amirshahrokhi K1, Bohlooli S.
  84. Cytokine. 2015 Feb;71(2):223-31. doi: 10.1016/j.cyto.2014.11.001. Epub 2014 Nov 21. Methylsulfonylmethane inhibits NLRP3 inflammasome activation. Ahn H1, Kim J1, Lee MJ1, Kim YJ2, Cho YW3, Lee GS4.
  85. Invest New Drugs. 2010 Oct;28(5):703-13. doi: 10.1007/s10637-009-9289-6. Epub 2009 Jul 10. Dietary supplementation of silymarin protects against chemically induced nephrotoxicity, inflammation and renal tumor promotion response. Kaur G1, Athar M, Alam MS.
  86. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4077-82. Epub 2007 Feb 27. Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway. Zhang WJ1, Wei H, Hagen T, Frei B.
  87. World J Gastroenterol. 2015 Sep 21;21(35):10091-103. doi: 10.3748/wjg.v21.i35.10091. Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury. Yoshida K1, Ushida Y1, Ishijima T1, Suganuma H1, Inakuma T1, Yajima N1, Abe K1, Nakai Y1.
  88. Chem Biol Interact. 2007 Jan 30;165(2):146-54. Epub 2006 Dec 2. Hepatocyte susceptibility to glyoxal is dependent on cell thiamin content. Shangari N1, Mehta R, O'brien PJ.
  89. Am J Physiol Endocrinol Metab. 2016 Jan 19:ajpendo.00260.2015. doi: 10.1152/ajpendo.00260.2015. [Epub ahead of print] Changes in one-carbon metabolism after duodenal-jejunal bypass surgery. Jung J1, Ha TK2, Lee J3, Lho Y4, Nam M3, Lee D3, le Roux CW5, Ryu DH6, Ha E4, Hwang GS7.
  90. Toxicology. 2001 Aug 28;165(2-3):217-24. Carbon tetrachloride-induced changes in the activity of phase II drug-metabolizing enzyme in the liver of male rats: role of antioxidants. Sheweita SA1, Abd El-Gabar M, Bastawy M.
  91. Hum Exp Toxicol. 2003 Mar;22(3):129-36. Protective role of ascorbic acid and alpha-tocopherol on arsenic-induced microsomal dysfunctions. Ramanathan K1, Shila S, Kumaran S, Panneerselvam C.
  92. Altern Med Rev. 1998 Apr;3(2):114-27. Clinical applications of N-acetylcysteine. Kelly GS1.
  93. Chem Biol Interact. 2013 Jan 25;201(1-3):9-18. doi: 10.1016/j.cbi.2012.10.027. Epub 2012 Nov 16. Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats. Ahmad I1, Shukla S, Kumar A, Singh BK, Kumar V, Chauhan AK, Singh D, Pandey HP, Singh C.
  94. Food Chem Toxicol. 2012 Dec;50(12):4375-81. doi: 10.1016/j.fct.2012.08.045. Epub 2012 Aug 30. Modulation of CYP1A1, CYP1B1 and DNA adducts level by green and white tea in Balb/c mice. Kumar M1, Jain M, Sehgal A, Sharma VL.
  95. Food Chem Toxicol. 2008 Apr;46(4):1271-8. Epub 2007 Oct 17. Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG. Na HK1, Surh YJ.
  96. Toxicol Lett. 2007 May 15;170(3):238-47. Epub 2007 Mar 24. Curcumin activates human glutathione S-transferase P1 expression through antioxidant response element. Nishinaka T1, Ichijo Y, Ito M, Kimura M, Katsuyama M, Iwata K, Miura T, Terada T, Yabe-Nishimura C.
  97. Pharmacol Rep. 2014 Feb;66(1):87-92. doi: 10.1016/j.pharep.2013.08.009. Epub 2014 Feb 1. The effect of lipoic acid on cyanate toxicity in the rat heart. Sokołowska M1, Kostański M2, Lorenc-Koci E3, Bilska A2, Iciek M2, Włodek L2.
  98. Br J Nutr. 2014 Aug 14;112(3):295-308. doi: 10.1017/S0007114514000841. Epub 2014 Apr 30. Effect of dietary α-lipoic acid on the mRNA expression of genes involved in drug metabolism and antioxidation system in rat liver. Ide T1.
  99. Biochim Biophys Acta. 2009 Oct;1790(10):1149-60. doi: 10.1016/j.bbagen.2009.07.026. Epub 2009 Aug 4. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Shay KP1, Moreau RF, Smith EJ, Smith AR, Hagen TM.
  100. Int J Oncol. 2008 Oct;33(4):833-8. Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by alpha-lipoic acid in human leukemia HL-60 cells. Elangovan S1, Hsieh TC.
  101. Toxicol Appl Pharmacol. 2015 Jan 1;282(1):52-60. doi: 10.1016/j.taap.2014.11.004. Epub 2014 Nov 18. Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1. Techapiesancharoenkij N1, Fiala JL2, Navasumrit P1, Croy RG2, Wogan GN2, Groopman JD3, Ruchirawat M1, Essigmann JM4.
  102. J Food Sci. 2011 Sep;76(7):H175-81. doi: 10.1111/j.1750-3841.2011.02311.x. Epub 2011 Aug 22. Cruciferous vegetable phytochemical sulforaphane affects phase II enzyme expression and activity in rat cardiomyocytes through modulation of Akt signaling pathway. Leoncini E1, Malaguti M, Angeloni C, Motori E, Fabbri D, Hrelia S.
  103. J Agric Food Chem. 2004 Apr 7;52(7):1867-71. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds. Munday R1, Munday CM.
  104. J Environ Manage. 2008 Apr;87(1):46-58. Epub 2007 May 11. Immobilization of Pb(II), Cd(II) and Ni(II) ions on kaolinite and montmorillonite surfaces from aqueous medium. Sen Gupta S1, Bhattacharyya KG.
  105. J Environ Sci Eng. 2013 Jul;55(3):371-6. Accumulation of heavy metals (Cu, Cr, Pb and Cd) in freshwater micro algae (Chlorella sp.). Kumar RM, Frankilin J, Raj SP.
  106. Bioresour Technol. 2013 May;136:604-9. doi: 10.1016/j.biortech.2013.03.043. Epub 2013 Mar 15. Chromate tolerance and accumulation in Chlorella vulgaris L.: role of antioxidant enzymes and biochemical changes in detoxification of metals. Rai UN1, Singh NK, Upadhyay AK, Verma S.

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